nPOD 12th Annual Scientific Meeting SEND IN YOUR LATE BREAKING ABSTRACT There is much anticipation for this event and we encourage each nPOD Investigator to submit abstracts of research utilizing nPOD resources. Deadline for late breaking abstract submission is Monday, December 2, 2019. Please use this template to prepare your abstract(s) and email them to Monica Novak. […]
Year: 2018
nPOD Case Deep Dive: #6243
DATE: Tuesday, October 24th, 2017 SPEAKERS: nPOD Investigators, group discussion led by Alberto Puglese, MD Click here to view a recording of the webinar. The nPOD “Deep Dive” Case Study webinar series aims to unite the efforts, expertise, and resources of various Investigators within the nPOD cohort in order to paint a uniquely detailed […]
Welcome Dr. Carmella Evans-Molina
Welcome Dr. Carmella Evans-Molina New nPOD Co-Executive Director We are so honored and happy to announce that Carmella Evans-Molina, MD, PhD has joined the Network for Pancreatic Organ donors with Diabetes (nPOD) program to serve as a Co-Executive Director and be part of the leadership team. Carmella is a physician scientist with strong type 1 […]
Tissue Distribution and Clonal Diversity
Tissue Distribution and Clonal Diversity Autoreactive CD4+ and CD8+ T cells have been identified from the peripheral blood and islets of type 1 diabetes (T1D) patients and organ donors, and autoantibodies secreted by autoreactive B cells are the most widely used biomarker of T1D. However, the T1D adaptive immune repertoire had not been examined without […]
Analysis of Self Antigen Specificity
Self-Antigen Specificity of Islet-Infiltrating T-cells Autoreactive T cells specific for beta cell antigens have previously been identified from the peripheral blood of type 1 diabetes (T1D) patients, and immune cells within the pancreatic insulitis lesion been immunophenotyped from human organ donor tissues. However, this report by Babon et al. represents one of the first and […]
2018 Publications (9)
Richardson SJ, Morgan NG. (2018) Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention. Curr Opin Pharmacol. 2018 Jul 28;43:11-19. doi: 10.1016/j.coph.2018.07.006. Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, Richardson SJ. (2018) Unexpected subcellular distribution of a […]
Pancreatic Islet Cell Hyperexpression
Pancreatic Islet Cell Hyperexpression Pancreatic islet cell hyperexpression of HLA class-I was first observed from a small number of autopsy specimens from type 1 diabetes (T1D) patients in the 1980s, but in recent years, this notion was challenged as a potential artifact. Richardson et al. performed immunohistochemistery, immunofluorescence, and Affymetrix array analysis of RNA isolated […]
2018 nPOD Annual Meeting Agenda
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nPOD Islet Isolation Program (IIP)
Introducing the New nPOD Islet Isolation Program (IIP) & Planning Webinar Dear Colleagues and nPOD Investigators: You may be aware that nPOD has recently received renewed financial support from the Breakthrough T1D and the Helmsley Charitable Trust, and will continue to recover tissues from organ donors in support of T1D research. As part of this […]