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ORIGINAL

Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk

Syed F, Krishnan P, Chang G, Rana J, Langlais SR, Hati S, Yamada K, Lam AK, Talware S, Del Carmen Aquino J, Hagedorn E, Liu X, Sardar R, Liu J, Mirmira RG, Evans-Molina C. Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk. Diabetologia. 2026 Apr 21. doi: 10.1007/s00125-026-06720-7. Epub ahead of print. PMID: 42012684.

ORIGINAL

Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices

Becker MW, Brown ME, Wiseman K, Chiodetti AL, Huber MK, Cuaycal AE, Sintara P, Ferreira SM, Smurlick D, Barra JM, Ladd AM, Drotar DM, Atkinson MA, Weber P, Al-Mossawi H, Russ HA, Mahon TM, Brusko TM, Bossi G, Phelps EA. Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices. Sci Adv. 2026 Apr 3;12(14):eaec9029. doi: 10.1126/sciadv.aec9029. Epub 2026 Apr 1. PMID: 41920992; PMCID: PMC13041756.

ORIGINAL

Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development

Peters LD, Seay HR, Smith J, Posgai AL, Berkowitz R, Wasserfall CH, Atkinson MA, Bacher R, Brusko MA, Brusko TM. Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development. bioRxiv [Preprint]. 2026 Apr 1:2025.05.23.655848. doi: 10.1101/2025.05.23.655848. PMID: 41959012; PMCID: PMC13060253.

ORIGINAL

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Reardon S, Posgai AL, Bacher R, Luning Prak ET, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes. Cell Rep. 2026 Mar 23;45(4):117144. doi: 10.1016/j.celrep.2026.117144. Epub ahead of print. PMID: 41875135.

ORIGINAL

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Rawat P, Shapiro MR, Peters LD, Widrich M, Mayer-Blackwell K, Motwani K, Pavlović M, Al Hajj G, Posgai AL, Kanduri C, Isacchini G, Chernigovskaya M, Scheffer L, Motwani K, Balzano-Nogueira LO, Pettenger-Willey CM, Valkiers S, Jacobsen LM, Haller MJ, Schatz DA, Wasserfall CH, Emerson RO, Fiore-Gartland AJ, Atkinson MA, Klambauer G, Sandve GK, Greiff V, Brusko TM. Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood. Sci Adv. 2026 Feb 13;12(7):eadx7448. doi: 10.1126/sciadv.adx7448. Epub 2026 Feb 13. PMID: 41686902; PMCID: PMC12904210.

ORIGINAL

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis

Mummey HM, Corban S, Lucero J, Melton RL, Pittigher M, Johnston VC, Deutsch GH, D’Antonio-Chronowska A, Wang A, Hull-Meichle RL, Gaulton KJ. Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis. bioRxiv [Preprint]. 2025 Dec 16:2025.12.14.694120. doi: 10.64898/2025.12.14.694120. PMID: 41446239; PMCID: PMC12724667.

ORIGINAL

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes

Kelly S, Sarkar S, Williams SM, Fu AD, Butterworth EA, Sagendorf TJ, Nierves LA, Kwon Y, Li X, Petyuk VA, Chen J, Nakayasu ES, Atkinson MA, Kulkarni RN, Mathews CE, Zhu Y, Campbell-Thompson M, Qian WJ. Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes. bioRxiv [Preprint]. 2025 Nov 12:2025.11.10.687674. doi: 10.1101/2025.11.10.687674. PMID: 41292817; PMCID: PMC12642322.

ORIGINAL

Small things matter: Lack of extra-islet beta cells in Type 1 diabetes

Murrall K, Luckett T, Lekka C, Flaxman CS, Wyatt R, Akhbari P, Kusmartseva I, Hunter SL, Leete P, Burn I, Osokina E; EXE-T1D Consortium; Shaw JAM, Morgan NG, Richardson SJ. Small things matter: Lack of extraislet β cells in type 1 diabetes. Sci Adv. 2025 Nov 14;11(46):eadz2251. doi: 10.1126/sciadv.adz2251. Epub 2025 Nov 12. PMID: 41223263; PMCID: PMC12609120.

ORIGINAL

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

Becker MW, Brown M, Wiseman K, Chiodetti AL, Huber MK, Cuaycal AE, Sintara P, Ferreira SM, Smurlick D, Barra JM, Ladd AM, Drotar DM, Atkinson MA, Weber P, Al-Mossawi H, Russ HA, Mahon TM, Brusko TM, Bossi G, Phelps EA. Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices. bioRxiv [Preprint]. 2025 Oct 22:2025.10.21.683528. doi: 10.1101/2025.10.21.683528. PMID: 41278996; PMCID: PMC12633349.

ORIGINAL

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

Forjaz A, Queiroga Y, Hernandez A, Crawford A, Qin X, Zhong M, Tsaoatsis M, Joshi S, Kramer D, Nizet O, Bea H, Li Y, Qin S, O’Flynn R, Yang M, Pratt B, Wu F, Gensbigler P, Blecher M, Wu PH, Kagohara LT, Shih lM, Zwicker D, Atkinson M, Shi L, Fan R, Kiemen AL, Wirtz D. 3D multi-omic mapping of whole nondiseases human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors. bioRxiv [Preprint]. 2025 Sep 21. doi: 10.1101/2025.09.21.677628.

ORIGINAL

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

Quesada-Masachs E, Zilberman S, Chu T, McArdle S, Kiosses WB, Rajendran S, Atkinson MA, Benkahla MA, Mikulski Z, von Herrath M. Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes. bioRxiv [Preprint]. 2025 Sep 17:2025.09.13.676053. doi: 10.1101/2025.09.13.676053. PMID: 41000615; PMCID: PMC12458208.