Publications

Steenbuck N, Damond N, Engler S, Kusmartseva I, Posgai AL, Drotar DM, Williams MD, de Souza N, Brusko TM, Brusko MA, Wasserfall CH, Atkinson MA, Bodenmiller B. Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata. Nat Metab. 2026 Jul 2. doi: 10.1038/s42255-026-01559-z. Epub ahead of print. PMID: 42393283.

Kang S, Maya N, Morillo M, Outar M, Posgai AL, Lamb DG, Campbell-Thompson M, Kim S. Deep learning-powered quantification of endocrine cells and CD3⁺ T cells in the natural history of type 1 diabetes. Diabetologia. 2026 May 7. doi: 10.1007/s00125-026-06742-1. Epub ahead of print. PMID: 42096070.

Syed F, Krishnan P, Chang G, Rana J, Langlais SR, Hati S, Yamada K, Lam AK, Talware S, Del Carmen Aquino J, Hagedorn E, Liu X, Sardar R, Liu J, Mirmira RG, Evans-Molina C. Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk. Diabetologia. 2026 Apr 21. doi: 10.1007/s00125-026-06720-7. Epub ahead of print. PMID: 42012684.

Du J, Manna AK, Hughes EP, Bisoma P, Evason KJ, Young A, Wilson WD, Farahat AA, Tantin D. OCA-B/Pou2af1 Expression in Mouse T Cells Promotes PD-1 Blockade-Induced Autoimmunity but is Dispensable for Anti-Tumor Immunity. bioRxiv [Preprint]. 2025 Oct 23:2025.10.22.683978. doi: 10.1101/2025.10.22.683978. PMID: 41279867; PMCID: PMC12633460.

Becker MW, Brown ME, Wiseman K, Chiodetti AL, Huber MK, Cuaycal AE, Sintara P, Ferreira SM, Smurlick D, Barra JM, Ladd AM, Drotar DM, Atkinson MA, Weber P, Al-Mossawi H, Russ HA, Mahon TM, Brusko TM, Bossi G, Phelps EA. Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices. Sci Adv. 2026 Apr 3;12(14):eaec9029. doi: 10.1126/sciadv.aec9029. Epub 2026 Apr 1. PMID: 41920992; PMCID: PMC13041756.

Peters LD, Seay HR, Smith J, Posgai AL, Berkowitz R, Wasserfall CH, Atkinson MA, Bacher R, Brusko MA, Brusko TM. Aberrant immune regulation and enrichment of stem-like CD8⁺ T cells in the pancreatic lymph node during type 1 diabetes development. bioRxiv [Preprint]. 2026 Apr 1:2025.05.23.655848. doi: 10.1101/2025.05.23.655848. PMID: 41959012; PMCID: PMC13060253.

Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Reardon S, Posgai AL, Bacher R, Luning Prak ET, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes. Cell Rep. 2026 Mar 23;45(4):117144. doi: 10.1016/j.celrep.2026.117144. Epub ahead of print. PMID: 41875135.

Rawat P, Shapiro MR, Peters LD, Widrich M, Mayer-Blackwell K, Motwani K, Pavlović M, Al Hajj G, Posgai AL, Kanduri C, Isacchini G, Chernigovskaya M, Scheffer L, Motwani K, Balzano-Nogueira LO, Pettenger-Willey CM, Valkiers S, Jacobsen LM, Haller MJ, Schatz DA, Wasserfall CH, Emerson RO, Fiore-Gartland AJ, Atkinson MA, Klambauer G, Sandve GK, Greiff V, Brusko TM. Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood. Sci Adv. 2026 Feb 13;12(7):eadx7448. doi: 10.1126/sciadv.adx7448. Epub 2026 Feb 13. PMID: 41686902; PMCID: PMC12904210.

Dewhurst-Trigg RE, Atkins J, Morgan NG, Eichmann M, Richardson SJ, Rackham CL. Characterisation of human pancreatic mesenchymal stromal cells in type 1 diabetes. Diabetologia. 2025 Dec 21. doi: 10.1007/s00125-025-06634-w. Epub ahead of print. PMID: 41422462.

Mummey HM, Corban S, Lucero J, Melton RL, Pittigher M, Johnston VC, Deutsch GH, D’Antonio-Chronowska A, Wang A, Hull-Meichle RL, Gaulton KJ. Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis. bioRxiv [Preprint]. 2025 Dec 16:2025.12.14.694120. doi: 10.64898/2025.12.14.694120. PMID: 41446239; PMCID: PMC12724667.

Rippa A, Posgai AL, Currlin S, Brusko M, Williams MD, Kaddis JS, Kusmartseva I, Wasserfall CH, Campbell-Thompson M, Atkinson MA. 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes. Nat Commun. 2025 Dec 11;16(1):11379. doi: 10.1038/s41467-025-66198-6. PMID: 41381473; PMCID: PMC12727770.

Kusmartseva I, Posgai A, Yang M, Oram R, Atkinson M, Pugliese A, Evans-Molina C. The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes. Cold Spring Harb Perspect Med. 2025 Dec 1;15(12):a041588. doi: 10.1101/cshperspect.a041588. PMID: 39134385; PMCID: PMC12667406.

Préfontaine C, Pipella J, Rampazzo Morelli N, Chen YC, Verchere CB, Thompson PJ. Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells. Diabetologia. 2026 Feb;69(2):421-435. doi: 10.1007/s00125-025-06603-3. Epub 2025 Nov 13. PMID: 41231256; PMCID: PMC12779684.

Kelly S, Sarkar S, Williams SM, Fu AD, Butterworth EA, Sagendorf TJ, Nierves LA, Kwon Y, Li X, Petyuk VA, Chen J, Nakayasu ES, Atkinson MA, Kulkarni RN, Mathews CE, Zhu Y, Campbell-Thompson M, Qian WJ. Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes. bioRxiv [Preprint]. 2025 Nov 12:2025.11.10.687674. doi: 10.1101/2025.11.10.687674. PMID: 41292817; PMCID: PMC12642322.

Murrall K, Luckett T, Lekka C, Flaxman CS, Wyatt R, Akhbari P, Kusmartseva I, Hunter SL, Leete P, Burn I, Osokina E; EXE-T1D Consortium; Shaw JAM, Morgan NG, Richardson SJ. Small things matter: Lack of extraislet β cells in type 1 diabetes. Sci Adv. 2025 Nov 14;11(46):eadz2251. doi: 10.1126/sciadv.adz2251. Epub 2025 Nov 12. PMID: 41223263; PMCID: PMC12609120.

Becker MW, Brown M, Wiseman K, Chiodetti AL, Huber MK, Cuaycal AE, Sintara P, Ferreira SM, Smurlick D, Barra JM, Ladd AM, Drotar DM, Atkinson MA, Weber P, Al-Mossawi H, Russ HA, Mahon TM, Brusko TM, Bossi G, Phelps EA. Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices. bioRxiv [Preprint]. 2025 Oct 22:2025.10.21.683528. doi: 10.1101/2025.10.21.683528. PMID: 41278996; PMCID: PMC12633349.

Johansen CG, Lam K, Farnsworth NL. Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes. bioRxiv [Preprint]. 2025 Jun 27:2025.06.25.661601. doi: 10.1101/2025.06.25.661601. Update in: Front Endocrinol (Lausanne). 2025 Oct 10;16:1675043. doi: 10.3389/fendo.2025.1675043. PMID: 40667128; PMCID: PMC12262395.

Geravandi, S., Liu, H., Pahwa, H. et al. The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes. Nat Commun 16, 8882 (2025). https://doi.org/10.1038/s41467-025-64508-6

Selaru F, Phillip JM, Wirtz D, Wu PH. NLTD 2.0: A Nonlinear Framework for Robust and Customizable Color Deconvolution in Histopathology. bioRxiv [Preprint]. 2025 Oct 3:2025.10.02.679756. doi: 10.1101/2025.10.02.679756. PMID: 41256483; PMCID: PMC12622035.

Forjaz A, Queiroga Y, Hernandez A, Crawford A, Qin X, Zhong M, Tsaoatsis M, Joshi S, Kramer D, Nizet O, Bea H, Li Y, Qin S, O’Flynn R, Yang M, Pratt B, Wu F, Gensbigler P, Blecher M, Wu PH, Kagohara LT, Shih lM, Zwicker D, Atkinson M, Shi L, Fan R, Kiemen AL, Wirtz D. 3D multi-omic mapping of whole nondiseases human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors. bioRxiv [Preprint]. 2025 Sep 21. doi: 10.1101/2025.09.21.677628.