nPOD - Type 1 Diabetes

HIRN Emerging Leader Funding Initiative

HIRN is proud to announce the HIRN Emerging Leader funding initiative aimed to provide support and protected time for senior postdoctoral fellows seeking to pursue studies that will enhance their transition toward independent research careers. Applications are sought from experienced postdoctoral fellows with a minimum of two years of ongoing postdoctoral experience who intend to continue research careers in scientific areas supported by the HIRN. This opportunity is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial that is itself comprised of a clinical trial intervention.

HIRN Emerging Leaders Information

A World without Type 1 Diabetes

Our Mission

Our mission is to find a way to prevent or reverse Type 1 Diabetes permanently, eliminating the need for lifelong insulin therapy and mitigate related complications. Through in-depth exploration of the disease’s intricate mechanisms, we challenge outdated scientific paradigms, paving the ways to future where revolutionary breakthroughs in treatment and prevention become not just possible, but inevitable.

Our Core Values

Our foundational principles center on appreciation, integrity, innovation and collaboration. We are deeply value the profound decision families make to contribute to T1D research through organ donation. We strive to utilize their gifts in the most meaning and impactful ways possible. By adapting new approaches and fostering a collaborative environment, we unite bright minds and their collective expertise to accelerates the path towards a cure Type 1 diabetes.

Investigator Resources

Online Pathology Information

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Featured Projects & Publications

We are united in one goal to cure Type 1 Diabetes.

T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes

Guyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA. T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes. Diabetologia; 2025.

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, et al. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. Cold Spring Harbor Laboratory; 2025.

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, et al. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. Cold Spring Harbor Laboratory; 2025.

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A Joint Partnership

The Leona M. and Harry B. Helmsley Charitable Trust