nPOD - Type 1 Diabetes

Helmsley T1D Program Request for Proposals

Helmsley’s Type 1 Diabetes Program is accepting concept notes through April 30^th for projects exploring the role of innate immunity in the development of T1D.

Learn More and Apply Here!

HIRN Data Scholars Initiative

The Human Islet Research Network (HIRN) announces a new funding initiative to support the use of existing HIRN datasets and resources to explore unique and innovative hypotheses designed to accelerate breakthroughs and advances in type 1 diabetes (T1D) research.

Learn More and Apply Here!

A World without Type 1 Diabetes

Our Mission

Our mission is to find a way to prevent or reverse Type 1 Diabetes permanently, eliminating the need for lifelong insulin therapy and mitigate related complications. Through in-depth exploration of the disease’s intricate mechanisms, we challenge outdated scientific paradigms, paving the ways to future where revolutionary breakthroughs in treatment and prevention become not just possible, but inevitable.

Our Core Values

Our foundational principles center on appreciation, integrity, innovation and collaboration. We are deeply value the profound decision families make to contribute to T1D research through organ donation. We strive to utilize their gifts in the most meaning and impactful ways possible. By adapting new approaches and fostering a collaborative environment, we unite bright minds and their collective expertise to accelerates the path towards a cure Type 1 diabetes.

Investigator Resources

Online Pathology Information

Request Data Samples

Data Portal

Featured Projects & Publications

We are united in one goal to cure Type 1 Diabetes.

Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression

Heide V van der, McArdle S, Nelson MS, Cerosaletti K, Gnjatic S, Mikulski Z, et al. Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression. Cold Spring Harbor Laboratory; 2025.

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, et al. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. Cold Spring Harbor Laboratory; 2025.

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, et al. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. Cold Spring Harbor Laboratory; 2025.

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