WE ARE UNITED IN ONE GOAL TO CURE TYPE 1 DIABETES

A World without Type 1 Diabetes

Our Mission  

Find a way to prevent or reverse Type 1 Diabetes permanently, eliminating the need for lifelong insulin therapy and mitigate related complications. Through in-depth exploration of the disease’s intricate mechanisms, we challenge outdated scientific paradigms, paving the ways to future where revolutionary breakthroughs in treatment and prevention become not just possible, but inevitable.

Our Core Values

Appreciation, integrity, innovation and collaboration. We deeply value the profound decision families make to contribute to T1D research through organ donation. We strive to utilize their gifts in the most meaningful and impactful ways possible. By adapting new approaches and fostering a collaborative environment, we unite bright minds and their collective expertise to accelerate the path towards a cure for Type 1 diabetes.

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Featured Projects & Publications

We are united in one goal to cure Type 1 Diabetes.

T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes

Guyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA. T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes. Diabetologia; 2025.

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, et al. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. Cold Spring Harbor Laboratory; 2025.

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, et al. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. Cold Spring Harbor Laboratory; 2025.

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A Joint Partnership

The Leona M. and Harry B. Helmsley Charitable Trust
Breakthrough T1D