A well–recognized feature of pancreatic ß–cells is their limited expression of endogenous antioxidants. From recent support by nPOD and HIRN/CBDS, my lab made the entirely novel observation, using metabolic labeling in pancreatic slices derived from 5 T1D donors, that disulfide–bond formation (i.e., folding) of newly–synthesized (radiolabeled) proinsulin is dramatically impaired with a surprisingly large fraction […]