The different cellular compartments of the pancreas have a high degree of plasticity, which, if harnessed, could have important therapeutic implications for beta-cell regeneration in type 1 and type 2 diabetes. This proposal focuses on high-resolution characterization of ductal progenitor-like cells (P2RY1+/ALK3+) and exocrine-endocrine communication in live human pancreatic slices. We will use dynamic single-cell […]