Category: Immunology

T cell autoreactivity in pancreatic draining lymph nodes (pLN) of donors with cystic fibrosis-related diabetes (CFRD) and type 1 diabetes (T1D)

Many individuals with cystic fibrosis (CF) develop diabetes or CF–related diabetes (CFRD).Some published data indicates that CFRD shares autoimmune phenotypes in common with type 1 diabetes (T1D). These include a higher prevalence of islet autoantibodies for CFRD patients than the general population and signs of broad immune dysregulation (including a Th17 signature). Notably, in autoantibody–positive […]