Category: Immunology

Impact of human islet myeloid signaling via TREM1 and MERTK signaling on T cell responses in T1D

Type 1 diabetes (T1D) is driven by autoimmune destruction of pancreatic islets, where local interactions between islet myeloid cells and autoreactive T cells play a pivotal role in disease progression. However, the phenotypicdiversity and functional impact of distinct myeloid subsets within human islets remain poorly understood. Our preliminary data demonstrates that antigenic interactions between islet […]