Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single cell RNA-sequencing (scRNA-seq) to identify T cell receptors (TCRs) in IAR T cells, we identified a multi-specific class of T1D-associated T cell receptors (TCRs) that share TCR alpha chains […]
Year: 2021
Lipid droplet distribution study in human pancreas
In collaboration with Dr. Alvin Powers’ at Vanderbilt University, we showed by electron microscopy (EM) that transplanted human islets have a much higher level of lipid droplets (LDs) than transplanted mouse islets (1). Moreover, we found that the number of LDs in transplanted human islets was increased in high fat diet (HFD) fed mouse recipients. […]
2022 nPOD Annual Scientific Meeting
THANK YOU FOR ATTENDING The Network for Pancreatic Organ donors with Diabetes (nPOD) hosted its 14th Annual Meeting from January 30 – February 2, 2022 at the One Ocean Resort & Spa.
COVID-19, Diabetes, and nPOD
The COVID-19 pandemic has impacted all aspects of life, worldwide. At nPOD, we essentially never ceased operations in terms of donor recoveries. With testing of nPOD donors for Sars-Cov-2, we received 304 offers and nPOD received tissues from 21 cases over the last year (including 3 AAb+ and 6 donors with T1D, of whom two […]
Macrophages in Type 1 Diabetes
DATE: Thursday, December 10th, 2020 TIME: 11:00am – 01:00pm EST Download Meeting Recording: Dropbox link to view meeting recording Discussion led by: Hubert Tse, PhD, Joana Collares Pereira Almaca, PhD, Xiangwei Xiao, MD, PhD, and Bruce Verchere, PhD
nPOD Pancreas Slices Group: Islet Biology Part 2
DATE: Wednesday, July 14th, 2021 TIME: 11:00am – 01:00pm EST A webinar session to discuss emerging results from nPOD investigators: Ricardo Pastori/Juan Dominguez-Bendala Richard Benninger Emily Sims and the Pro-Hormone Working Group Hubert Tse/Jared Taylor Matthias von Herrath/Mehdi Benkahla
Innate Immunity in Type 1 Diabetes in nPOD Donors
DATE: Thursday, July 22nd, 2021 TIME: 11:00am – 01:00pm EST Download Meeting Recording: Dropbox link to view meeting recording Discussion led by: Alberto Pugliese, MD, Sally Kent, PhD, Hubert Tse, PhD, Bruce Verchere, PhD, Xiangwei Xiao, MD, PhD and Rachel Friedman, PhD Last December, we held a stimulating webinar on the role of macrophages in type 1 diabetes. […]
nPOD Pancreas Slices Group Immunology
DATE: Friday, July 16th, 2021 TIME: 11:00am – 01:00pm EST Discussion led by: Irina Kusmartseva, PhD, Maria Beery, MS, and Helmut Hiller, MS
nPOD Pancreas Slices Group: Islet Biology Part 1
DATE: Thursday, July 8th, 2021 TIME: 11:00am – 01:00pm EST Discussion led by: Irina Kusmartseva, PhD, Maria Beery, MS, and Helmut Hiller, MS
Understanding diabetes progression via tissue chemical imaging
Type 1 diabetes (T1D) is a devastating multifactorial disorder manifested by the autoimmune destruction of insulin-producing beta cells leading to insulin deficiency. Our overarching aim is to investigate the spaciochemical changes in the human exocrine and endocrine pancreata during various stages of T1D with unmatched chemical specificity and multiplexity. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry […]
Islet Pathology in Cystic Fibrosis
Insulin deficiency is a common feature of cystic fibrosis (CF), resulting in CF-related diabetes (CFRD) in ~20% of adolescents and ~50% of adults with the disease. The clinical consequences of insulin deficiency in CF are significant – CFRD is associated with worsened CF lung disease and increased morbidity and mortality. The loss of exocrine pancreatic […]
2021 nPOD Annual Meeting
REGISTER TODAY JOIN US FOR AN INTERACTIVE VIRTUAL SCIENTIFIC SESSION DOWNLOAD MEETING AGENDA **Please Note: Zoom Meeting links are NOT active at this time. Details about access to the virtual meeting and logistics will be communicated soon** The Network for Pancreatic Organ donors with Diabetes (nPOD) will host its 13th Annual Meeting as a virtual […]