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ORIGINAL

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Rawat P, Shapiro MR, Peters LD, Widrich M, Mayer-Blackwell K, Motwani K, Pavlović M, Al Hajj G, Posgai AL, Kanduri C, Isacchini G, Chernigovskaya M, Scheffer L, Motwani K, Balzano-Nogueira LO, Pettenger-Willey CM, Valkiers S, Jacobsen LM, Haller MJ, Schatz DA, Wasserfall CH, Emerson RO, Fiore-Gartland AJ, Atkinson MA, Klambauer G, Sandve GK, Greiff V, Brusko TM. Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood. Sci Adv. 2026 Feb 13;12(7):eadx7448. doi: 10.1126/sciadv.adx7448. Epub 2026 Feb 13. PMID: 41686902; PMCID: PMC12904210.

ORIGINAL

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis

Mummey HM, Corban S, Lucero J, Melton RL, Pittigher M, Johnston VC, Deutsch GH, D’Antonio-Chronowska A, Wang A, Hull-Meichle RL, Gaulton KJ. Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis. bioRxiv [Preprint]. 2025 Dec 16:2025.12.14.694120. doi: 10.64898/2025.12.14.694120. PMID: 41446239; PMCID: PMC12724667.

ORIGINAL

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes

Kelly S, Sarkar S, Williams SM, Fu AD, Butterworth EA, Sagendorf TJ, Nierves LA, Kwon Y, Li X, Petyuk VA, Chen J, Nakayasu ES, Atkinson MA, Kulkarni RN, Mathews CE, Zhu Y, Campbell-Thompson M, Qian WJ. Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes. bioRxiv [Preprint]. 2025 Nov 12:2025.11.10.687674. doi: 10.1101/2025.11.10.687674. PMID: 41292817; PMCID: PMC12642322.

ORIGINAL

Small things matter: Lack of extra-islet beta cells in Type 1 diabetes

Murrall K, Luckett T, Lekka C, Flaxman CS, Wyatt R, Akhbari P, Kusmartseva I, Hunter SL, Leete P, Burn I, Osokina E; EXE-T1D Consortium; Shaw JAM, Morgan NG, Richardson SJ. Small things matter: Lack of extraislet β cells in type 1 diabetes. Sci Adv. 2025 Nov 14;11(46):eadz2251. doi: 10.1126/sciadv.adz2251. Epub 2025 Nov 12. PMID: 41223263; PMCID: PMC12609120.

ORIGINAL

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

Becker MW, Brown M, Wiseman K, Chiodetti AL, Huber MK, Cuaycal AE, Sintara P, Ferreira SM, Smurlick D, Barra JM, Ladd AM, Drotar DM, Atkinson MA, Weber P, Al-Mossawi H, Russ HA, Mahon TM, Brusko TM, Bossi G, Phelps EA. Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices. bioRxiv [Preprint]. 2025 Oct 22:2025.10.21.683528. doi: 10.1101/2025.10.21.683528. PMID: 41278996; PMCID: PMC12633349.

ORIGINAL

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

Forjaz A, Queiroga Y, Hernandez A, Crawford A, Qin X, Zhong M, Tsaoatsis M, Joshi S, Kramer D, Nizet O, Bea H, Li Y, Qin S, O’Flynn R, Yang M, Pratt B, Wu F, Gensbigler P, Blecher M, Wu PH, Kagohara LT, Shih lM, Zwicker D, Atkinson M, Shi L, Fan R, Kiemen AL, Wirtz D. 3D multi-omic mapping of whole nondiseases human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors. bioRxiv [Preprint]. 2025 Sep 21. doi: 10.1101/2025.09.21.677628.

ORIGINAL

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

Quesada-Masachs E, Zilberman S, Chu T, McArdle S, Kiosses WB, Rajendran S, Atkinson MA, Benkahla MA, Mikulski Z, von Herrath M. Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes. bioRxiv [Preprint]. 2025 Sep 17:2025.09.13.676053. doi: 10.1101/2025.09.13.676053. PMID: 41000615; PMCID: PMC12458208.

ORIGINAL

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. Cell Rep. 2025 Aug 26;44(9):116174. doi: 10.1016/j.celrep.2025.116174. Epub ahead of print. PMID: 40875294.

ORIGINAL

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes

Drotar DM, Vazquez Ramos GJA, Williams MD, David ST, Luce C, Smith JA, Posgai AL, Bacher R, Campbell-Thompson M, Kusmartseva I, Brusko MA, Atkinson MA, Wasserfall CH. Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes. Diabetes. 2025 Jul 24:db250326. doi: 10.2337/db25-0326. Epub ahead of print. PMID: 40705030.

ORIGINAL

The antigen presentation landscape of cytokine-stressed human pancreatic islets

Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ. The antigen presentation landscape of cytokine-stressed human pancreatic islets. Cell Rep. 2025 Jul 18;44(8):115927. doi: 10.1016/j.celrep.2025.115927. PMID: 40684438.

ORIGINAL

Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123

Álvarez-Cubela S, Altilio ID, Doke M, Klein D, Tamayo A, Alcázar Ó, Santana CG, Qadir MMF, Alver CG, Cruz F, Biggs O, Tovar Castro JD, Navarro-Rubio B, Ricordi C, Caicedo A, Buchwald P, Agarwal A, Oltra E, Pastori RL, Domínguez-Bendala J. Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123. Nat Commun. 2025 Jul 3;16(1):6121. doi: 10.1038/s41467-025-61534-2. PMID: 40610457; PMCID: PMC12226732.