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ORIGINAL

The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes

Jones TLZ, Kusmartseva I, Litovsky S, Thakar R, Posgai AL, Eckel RH, Atkinson MA. The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes. Diabetes. 2025 Apr 24:db250017. doi: 10.2337/db25-0017. Epub ahead of print. PMID: 40272262.

ORIGINAL

Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue

Richardson SJ, Rodriguez-Calvo T, Laiho JE, Kaddis JS, Nyalwidhe JO, Kusmartseva I, Morfopoulou S, Petrosino JF, Plagnol V, Maedler K, Morris MA, Nadler JL, Atkinson MA, von Herrath M, Lloyd RE, Hyoty H, Morgan NG, Pugliese A; nPOD-Virus Group. Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06401-x. Epub ahead of print. PMID: 40090994.

ORIGINAL

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. bioRxiv [Preprint]. 2025 Mar 17:2025.02.13.637721. doi: 10.1101/2025.02.13.637721. PMID: 40027657; PMCID: PMC11870426.

ORIGINAL

Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes

Rodriguez-Calvo T, Laiho JE, Oikarinen M, Akhbari P, Flaxman C, Worthington T, Apaolaza P, Kaddis JS, Kusmartseva I, Tauriainen S, Campbell-Thompson M, Atkinson MA, von Herrath M, Hyöty H, Morgan NG, Pugliese A, Richardson SJ; nPOD-Virus group. Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06384-9. Epub ahead of print. PMID: 40090995.

ORIGINAL

Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease

Pala K, Sun KX, Krogvold L, Dahl-Jørgensen K, Reddy S. Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease. Cell Tissue Res. 2025 Mar 10. doi: 10.1007/s00441-025-03955-5. Epub ahead of print. PMID: 40059238.

ORIGINAL

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. bioRxiv [Preprint]. 2025 Mar 1:2024.12.29.630665. doi: 10.1101/2024.12.29.630665. PMID: 39763971; PMCID: PMC11703223.

ORIGINAL

Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells

Carré A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, Göransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells. Nat Commun. 2025 Jan 17;16(1):765. doi: 10.1038/s41467-025-55908-9. PMID: 39824805; PMCID: PMC11748642.

ORIGINAL

Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk

Akhtar MN, Hnatiuk A, Delgadillo-Silva L, Geravandi S, Sameith K, Reinhardt S, Bernhardt K, Singh SP, Maedler K, Brusch L, Ninov N. Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk. EMBO J. 2025 Feb;44(4):1131-1153. doi: 10.1038/s44318-024-00332-w. Epub 2025 Jan 6. PMID: 39762647; PMCID: PMC11833124.

ORIGINAL

The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

Barlow GL, Schürch CM, Bhate SS, Phillips D, Young A, Dong S, Martinez HA, Kaber G, Nagy N, Ramachandran S, Meng J, Korpos E, Bluestone JA, Nolan GP, Bollyky PL. The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes. medRxiv [Preprint]. 2024 Dec 14:2023.03.15.23287145. doi: 10.1101/2023.03.15.23287145. Update in: Elife. 2025 Apr 15;13:RP100535. doi: 10.7554/eLife.100535. PMID: 36993739; PMCID: PMC10055577.

ORIGINAL

Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube

Crawford AJ, Forjaz A, Bons J, Bhorkar I, Roy T, Schell D, Queiroga V, Ren K, Kramer D, Huang W, Russo GC, Lee MH, Wu PH, Shih IM, Wang TL, Atkinson MA, Schilling B, Kiemen AL, Wirtz D. Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube. Sci Adv. 2024 Sep 27;10(39):eadp6285. doi: 10.1126/sciadv.adp6285. Epub 2024 Sep 27. PMID: 39331707; PMCID: PMC11430475.

ORIGINAL

Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes

Laiho JE, Oikarinen S, Morfopoulou S, Oikarinen M, Renner A, Depledge D, Ross MC, Gerling IC, Breuer J, Petrosino JF, Plagnol V, Pugliese A, Toniolo A, Lloyd RE, Hyöty H; JDRF nPOD-Virus Group. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv [Preprint]. 2024 Sep 13:2024.09.11.24313112. doi: 10.1101/2024.09.11.24313112. Update in: Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06359-w. PMID: 39314969; PMCID: PMC11419248.