Publications

van der Heide V, McArdle S, Nelson MS, Cerosaletti K, Gnjatic S, Mikulski Z, Posgai AL, Kusmartseva I, Atkinson M, Homann D. Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression. bioRxiv [Preprint]. 2025 Mar 19:2025.03.18.644000. doi: 10.1101/2025.03.18.644000. PMID: 40166299; PMCID: PMC11956956.

Richardson SJ, Rodriguez-Calvo T, Laiho JE, Kaddis JS, Nyalwidhe JO, Kusmartseva I, Morfopoulou S, Petrosino JF, Plagnol V, Maedler K, Morris MA, Nadler JL, Atkinson MA, von Herrath M, Lloyd RE, Hyoty H, Morgan NG, Pugliese A; nPOD-Virus Group. Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06401-x. Epub ahead of print. PMID: 40090994.

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. bioRxiv [Preprint]. 2025 Mar 17:2025.02.13.637721. doi: 10.1101/2025.02.13.637721. PMID: 40027657; PMCID: PMC11870426.

Rodriguez-Calvo T, Laiho JE, Oikarinen M, Akhbari P, Flaxman C, Worthington T, Apaolaza P, Kaddis JS, Kusmartseva I, Tauriainen S, Campbell-Thompson M, Atkinson MA, von Herrath M, Hyöty H, Morgan NG, Pugliese A, Richardson SJ; nPOD-Virus group. Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06384-9. Epub ahead of print. PMID: 40090995.

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. bioRxiv [Preprint]. 2025 Mar 1:2024.12.29.630665. doi: 10.1101/2024.12.29.630665. PMID: 39763971; PMCID: PMC11703223.

Bahl V, Rifkind R, Waite E, Hamdan Z, May CL, Manduchi E, Voight BF, Lee MYY, Tigue M, Manuto N, Glaser B, Avrahami D, Kaestner KH. G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells. Sci Transl Med. 2025 Jan;17(779):eadi6148. doi: 10.1126/scitranslmed.adi6148. Epub 2025 Jan 1. PMID: 39742505.

Carré A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, Göransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells. Nat Commun. 2025 Jan 17;16(1):765. doi: 10.1038/s41467-025-55908-9. PMID: 39824805; PMCID: PMC11748642.

Akhtar MN, Hnatiuk A, Delgadillo-Silva L, Geravandi S, Sameith K, Reinhardt S, Bernhardt K, Singh SP, Maedler K, Brusch L, Ninov N. Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk. EMBO J. 2025 Feb;44(4):1131-1153. doi: 10.1038/s44318-024-00332-w. Epub 2025 Jan 6. PMID: 39762647; PMCID: PMC11833124.

Duinkerken, B.H.P., Alsahaf, A.M.J., Hoogenboom, J.P. et al. Automated analysis of ultrastructure through large-scale hyperspectral electron microscopy. npj Imaging 2, 53 (2024). https://doi.org/10.1038/s44303-024-00059-7

Kang S, Penaloza Aponte JD, Elashkar O, Morales JF, Waddington N, Lamb DG, Ju H, Campbell-Thompson M, Kim S. Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes. J Pathol Inform. 2024 Nov 8;16:100406. doi: 10.1016/j.jpi.2024.100406. PMID: 39720415; PMCID: PMC11665367.

Apaolaza PS, Chen YC, Grewal K, Lurz Y, Boulassel S, Verchere CB, Rodriguez-Calvo T. Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes. Diabetologia. 2024 Oct 15. doi: 10.1007/s00125-024-06275-5. PMID: 39404844.

Crawford AJ, Forjaz A, Bons J, Bhorkar I, Roy T, Schell D, Queiroga V, Ren K, Kramer D, Huang W, Russo GC, Lee MH, Wu PH, Shih IM, Wang TL, Atkinson MA, Schilling B, Kiemen AL, Wirtz D. Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube. Sci Adv. 2024 Sep 27;10(39):eadp6285. doi: 10.1126/sciadv.adp6285. Epub 2024 Sep 27. PMID: 39331707; PMCID: PMC11430475.

Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN. m⁶A mRNA methylation by METTL14 regulates early pancreatic cell differentiation. EMBO J. 2024 Sep 25. doi: 10.1038/s44318-024-00213-2. Epub ahead of print. PMID: 39322760.

Raval K, Jamshidi N, Seyran B, Salwinski L, Pillai R, Yang L, Ma F, Pellegrini M, Shin J, Yang X, Tudzarova S. Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis. Life Sci Alliance. 2024 Sep 23;7(12):e202402743. doi: 10.26508/lsa.202402743. PMID: 39313296; PMCID: PMC11420665.

Laiho JE, Oikarinen S, Morfopoulou S, Oikarinen M, Renner A, Depledge D, Ross MC, Gerling IC, Breuer J, Petrosino JF, Plagnol V, Pugliese A, Toniolo A, Lloyd RE, Hyöty H; JDRF nPOD-Virus Group. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv [Preprint]. 2024 Sep 13:2024.09.11.24313112. doi: 10.1101/2024.09.11.24313112. Update in: Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06359-w. PMID: 39314969; PMCID: PMC11419248.

Toniolo A, Maccari G, Camussi G. mRNA Technology and Mucosal Immunization. Vaccines (Basel). 2024 Jun 17;12(6):670. doi: 10.3390/vaccines12060670. PMID: 38932399; PMCID: PMC11209623.

Jevon D, Cottle L, Hallahan N, Harwood R, Samra JS, Gill AJ, Loudovaris T, Thomas HE, Thorn P. Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes. Diabetologia. 2024 May 30. doi: 10.1007/s00125-024-06180-x. Epub ahead of print. PMID: 38814445.

Xie G, Toledo MP, Hu X, Yong HJ, Sanchez PS, Liu C, Naji A, Irianto J, Wang YJ. NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing. BMC Genomics. 2024 Apr 30;25(1):427. doi: 10.1186/s12864-024-10335-w. PMID: 38689254.

Costanzo A, Clarke D, Holt M, Sharma S, Nagy K, Tan X, Kain L, Abe B, Luce S, Boitard C, Wyseure T, Mosnier LO, Su AI, Grimes C, Finn MG, Savage PB, Gottschalk M, Pettus J, Teyton L. Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature. J Immunol. 2024 Mar 1:ji2300769. doi: 10.4049/jimmunol.2300769. Epub ahead of print. PMID: 38426888.

F De Jesus D, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN. Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes. Nat Cell Biol. 2024 Feb 26. doi: 10.1038/s41556-024-01368-0. Epub ahead of print. PMID: 38409327.