DATE: Tuesday, July 26th, 2016
SPEAKER: Laura Jacobsen, MD
University of Florida
Click here to view a recording of the webinar.
The nPOD database offers a wealth of knowledge; consolidating a large series of cases and slides into a collective that provides valuable data towards common features for the disorder’s pathogenesis. However, extensive information also exists in individual cases, a feature that can offer unique insights into disease pathophysiology at a personalized level. These latter findings can be presented in a brief, case-based report focused around images, specifically using nPOD histological images.
The Clinical Images in Diabetes section within the journal Diabetes Care represents an exciting, new (July, 2016) forum for conveying case-reports. This section, developed in part with guidance from nPOD, is almost tailor-made for reporting nPOD cases. Indeed, two nPOD cases have already been accepted for publication and others are being considered. First, was nPOD case 6196, looking at a clinical case of type 1 diabetes (T1D) with positive GAD autoantibodies, but contradictory histology (numerous insulin-positive islets and amyloid present) (Diabetes Care 2016 Jul; 39(7): 1292-1294). The second report, nPOD case 6263, is in press and focuses again on contradictory findings between clinical/laboratory review and histological features. This case was also analyzed further in the setting of ethnicity as well as genetic findings of yet to be determined significance. These cases were chosen after our team, made up of pediatric endocrinologists and pathologists, reviewed the donor charts and available laboratory data in conjunction with the histological images and there were unexpected findings or unique characteristics. These cases, their reviewer critiques and ways to get started will be presented, as well as the criteria set forth by Diabetes Care for this Clinical Images in Diabetes section, to encourage nPOD investigators to, in like form, present additional interesting cases from the nPOD collection. This, for the purpose of furthering the notion of disease heterogeneity in T1D as well as to provide novel insights towards the various pathogenic mechanisms leading to diabetes.
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