Several lines of evidence, in particular genetic association data of antiviral response genes with T1D risk, point to a role of viral infections in T1D etiology. However, multiple questions remain about the causal mechanisms and the type of viruses implicated. To contribute to these research questions, we are using high throughput sequencing technologies to find traces of viral RNA in the nPOD pancreatic organ donor T1D cases. Our strategy is based on deep RNA sequencing combined with sequence enrichment for known viral sequences to maximize the sensitivity of viral sequence detection. We then use bioinformatics tools to separate human and viral reads, characterise these reads and eventually provide a description of the virome of nPOD samples.