Our project entitled humoral immunity investigates several serological aspects of Type 1 Diabetes (T1D). Our group also serves as the ELISA autoantibody core wherein we oversee the screening laboratories and together with the University of Colorado maintain quality assurance and control for this program. However we also conduct research into additional aspects of autoantibodies from nPOD such as Islet cell autoantibody assays on autologous tissue. From this the idea of looking for complement deposition in pancreas tissue of autoantibody positive donors as well as those with T1D arose. We published the findings in Diabetes Care and in sum we found that C4d deposition was mainly associated with blood vessels and the extracellular matrix that surrounds blood vessels an the pancreatic ducts. This was most pronounced in T1D pancreas tissues and was interpreted as evidence of ongoing inflammation of the pancreas in this disease.