ORIGINAL PROJECT: Established different skin fibroblast cell lines, both from control and T1D nPOD donors. Graciously offered this as a resource available to current nPOD investigators.

ADDENDUM: The pancreata of nPOD cases are some of the best characterized type 1 diabetes cases. The availability of beta cells from stem cells would greatly enhance this resource by providing the ability to both study the primary pancreas, as well as living beta cells or other cell types in a defined environment with the genotype of the patient. This project aims to generate cell lines for as many of the nPOD cases as possible, and to convert selected cell lines to iPS cells, and stem cell derived beta cells to determine whether disease phenotypes are cell-autonomous effects of the genotype, or acquired through interactions with the environment or with other cell types.