Raval K, Jamshidi N, Seyran B, Salwinski L, Pillai R, Yang L, Ma F, Pellegrini M, Shin J, Yang X, Tudzarova S. Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis. Life Sci Alliance. 2024 Sep 23;7(12):e202402743. doi: 10.26508/lsa.202402743. PMID: 39313296; PMCID: PMC11420665.
Toniolo A, Maccari G, Camussi G. mRNA Technology and Mucosal Immunization. Vaccines (Basel). 2024 Jun 17;12(6):670. doi: 10.3390/vaccines12060670. PMID: 38932399; PMCID: PMC11209623.
Jevon D, Cottle L, Hallahan N, Harwood R, Samra JS, Gill AJ, Loudovaris T, Thomas HE, Thorn P. Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes. Diabetologia. 2024 May 30. doi: 10.1007/s00125-024-06180-x. Epub ahead of print. PMID: 38814445.
Xie G, Toledo MP, Hu X, Yong HJ, Sanchez PS, Liu C, Naji A, Irianto J, Wang YJ. NKX2-2 based nuclei sorting on frozen human archival pancreas enables the enrichment of islet endocrine populations for single-nucleus RNA sequencing. BMC Genomics. 2024 Apr 30;25(1):427. doi: 10.1186/s12864-024-10335-w. PMID: 38689254.
Costanzo A, Clarke D, Holt M, Sharma S, Nagy K, Tan X, Kain L, Abe B, Luce S, Boitard C, Wyseure T, Mosnier LO, Su AI, Grimes C, Finn MG, Savage PB, Gottschalk M, Pettus J, Teyton L. Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature. J Immunol. 2024 Mar 1:ji2300769. doi: 10.4049/jimmunol.2300769. Epub ahead of print. PMID: 38426888.
F De Jesus D, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN. Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes. Nat Cell Biol. 2024 Feb 26. doi: 10.1038/s41556-024-01368-0. Epub ahead of print. PMID: 38409327.
Callebaut A, Guyer P, Derua R, Buitinga M, Manganaro A, Yi X, Sodré FMC, Vig S, Suleiman M, Marchetti P, Eizirik DL, Kent SC, Mathieu C, James EA, Overbergh L. CD4+ T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets. Diabetes. 2024 Feb 22:db230588. doi: 10.2337/db23-0588. Epub ahead of print. PMID: 38387030.
Drawshy Z, Neiman D, Fridlich O, Peretz A, Magenheim J, Rozo AV, Doliba NM, Stoffers DA, Kaestner KH, Schatz DA, Wasserfall C, Campbell-Thompson M, Shapiro J, Kaplan T, Shemer R, Glaser B, Klochendler A, Dor Y. DNA methylation-based assessment of cell composition in human pancreas and islets. Diabetes. 2024 Jan 24:db230704. Epub ahead of print. PMID: 38266068.
D’Addio F, Assi E, Maestroni A, Rossi G, Usuelli V, Petrazzuolo A, Nardini M, Loretelli C, Ben Nasr M, Fiorina P. TMEM219 regulates the transcription factor expression and proliferation of beta cells. Front Endocrinol (Lausanne). 2024 Jan 22;15:1306127. doi: 10.3389/fendo.2024.1306127. PMID: 38318298; PMCID: PMC10839017.
Alver CG, Álvarez-Cubela S, Altilio I, Hutchison E, Warrner E, Viso ME, Vitale G, Oliver D, Pastori RL, Dominguez-Bendala J, Agarwal A. SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices. Lab Chip. 2024 Jan 11. Epub ahead of print. PMID: 38205530.
Stolovich-Rain M, Fridlich O, Azulai S, Klochendler A, Anzi S, Magenheim J, Stein I, Mushasha F, Glaser B, Pikarsky E, Ben-Zvi D, Dor Y. Extensive elimination of acinar cells during normal postnatal pancreas growth. Cell Rep. 2023 Nov 22;42(12):113457. Epub ahead of print. PMID: 37995187.
Wright JJ, Eskaros A, Windon A, Bottino R, Jenkins R, Bradley AM, Aramandla R, Philips S, Kang H, Saunders DC, Brissova M, Powers AC. Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity. Diabetes. 2023 Oct 26:db230009. Epub ahead of print. PMID: 37881846.
Doke M, Álvarez-Cubela S, Klein D, Altilio I, Schulz J, Mateus Gonçalves L, Almaça J, Fraker CA, Pugliese A, Ricordi C, Qadir MMF, Pastori RL, Domínguez-Bendala J. Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage. Cell Metab. 2023 Oct 20:S1550-4131(23)00370-4. Epub ahead of print. PMID: 37898119.
Panzer JK, Caicedo A. A bright future for glucagon and alpha cell biology. J Endocrinol. 2023 Oct 1:JOE-22-0315. Epub ahead of print. PMID: 37888975.
Poma AM, Basolo A, Alì G, Bonuccelli D, Di Stefano I, Conti M, Mazzetti P, Sparavelli R, Vignali P, Macerola E, Pistello M, Santini F, Basolo F, Toniolo A. SARS-CoV-2 spread to endocrine organs is associated with obesity: an autopsy study of COVID-19 cases. Endocrine. 2023 Sep 12. Epub ahead of print. PMID: 37698811.
Chen YC, Taylor AJ, Fulcher JM, Swensen AC, Dai XQ, Komba M, Wrightson KLC, Fok K, Patterson AE, Klein Geltink RI, MacDonald PE, Qian WJ, Verchere CB. Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice. Diabetes. 2023 Sep 1;72(9):1277-1288. PMID: 37364047; PMCID: PMC10450824.
Mateus Gonçalves L, Fahd Qadir MM, Boulina M, Makhmutova M, Pereira E, Almaça J. Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes. Cell Rep. 2023 Aug 29;42(8):112913. j.celrep.2023.112913. Epub 2023 Aug 1. PMID: 37531253.
Cha J, Tong X, Walker EM, Dahan T, Cochrane VA, Ashe S, Russell R, Osipovich AB, Mawla AM, Guo M, Liu JH, Loyd ZA, Huising MO, Magnuson MA, Hebrok M, Dor Y, Stein R. Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity. JCI Insight. 2023 Aug 22;8(16):e166386. PMID: 37606041; PMCID: PMC10543725.
Cantley J, Eizirik DL, Latres E, Dayan CM. Islet cells in T1D: from recent advances to novel therapies – a symposium-based roadmap for future. J Endocrinol. 2023 Jul 1:JOE-23-0082. Epub ahead of print. PMID: 37493471.
Panzer JK, Caicedo A. Protocol to generate and utilize pancreatic tissue slices to study endocrine and exocrine physiology in situ from mouse and human tissue. STAR Protoc. 2023 Jun 30;4(3):102399. Epub ahead of print. PMID: 37392393.