Category: Current nPOD Projects

E-cadherin mediates developmental effects on the proliferation and the function of β-cells in the islet of Langerhans

In rodents and humans, the rate of beta cell proliferation declines rapidly after birth; formation of the islets of Langerhans begins perinatally and continues after birth. We tested whether increased levels of E-cadherin during islet formation mediate the decline in beta cell proliferation rate by contributing to a reduction of molecules that mediate cell replication. In vitro, a […]