Category: Current nPOD Projects

ORIGINAL: Immunohistochemical identification of molecular markers of oxidative and nitrosative stress in β-cells during the early stages of human type 1 diabetes mellitus ADDENDUM: Beta cell stress as an early preceding phase of autoimmune type 1 diabetes (T1D): Immunohistochemical assessment of markers of early beta cell vulnerability in newly-diagnosed and long-term diabetic cases

ORIGINAL: This research seeks immunohistochemical evidence of beta cell oxidative and nitrosative stress during various stages of T1D and whether such stressors are also present preceding and during the early onset of the disease. Antibodies to nitrotyrosine, a marker of peroxynitrite-mediated cell damage and to 8-hydroxy-2-deoxyguanosine (a marker of DNA oxidation) are being employed in […]