Diabetogenic B-lymphocyte activity may be enhanced by SHM induced increases in Ig antigen affinity. -SHM requires AID induced double strand DNA breaks repaired by RAD51 complex proteins. -AID is expressed at higher levels in B-lymphocytes from NOD mice than control strains -A small RAD51 blocking molecule specifically induces apoptosis of AID expressing B-lymphocytes from both […]