Category: Beta Cell Physiology and Dysfunction

The role of beta cell lysosomal dysfunction in diabetes autoimmunity

As alterations in autophagic flux may contribute to T1D, we are seeking to determine if particular lysosomal components of beta cell autophagy participate in or dysregulate this essential process. The focus of this addendum is on the enzyme cathepsin H as specific genetic variants in this gene have been identified as T1D–associated SNPs. Through these […]