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ORIGINAL

Syntaxin-4, a key exocytosis mediating protein, shows heterogeneous expression in insulin-positive cells of human donors with new-onset and longer duration of type 1 diabetes: comparison with non-diabetic autoantibody-positive and -negative donors

Potman J, Sun KX, Pala K, Krogvold L, Dahl-Jørgensen K, Reddy S. Syntaxin-4, a key exocytosis mediating protein, shows heterogeneous expression in insulin-positive cells of human donors with new-onset and longer duration of type 1 diabetes: comparison with non-diabetic autoantibody-positive and -negative donors. J Mol Histol. 2026 Jul 30;57(4):252. doi: 10.1007/s10735-026-10901-4. PMID: 42530697.

ORIGINAL

Single-nucleus transcriptomic analysis of pediatric pancreas reveals cellular heterogeneity and early neoplasia signatures during chronic pancreatitis

Ahmed F, Xie X, Dixit A, Moreno-Fernandez ME, Patel EH, Gurria J, Khoury K, Christian P, Bottino R, Kumaragurubaran R, Adeleke D, Wasserfall CH, Wang Y, Abu-El-Haijia M. Single-nucleus transcriptomic analysis of pediatric pancreas reveals cellular heterogeneity and early neoplasia signatures during chronic pancreatitis. medRxiv [Preprint]. 2026 Jul 4. doi: 10.64898/2026.07.01.26357053. Epub ahead of print.

ORIGINAL

Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata

Steenbuck N, Damond N, Engler S, Kusmartseva I, Posgai AL, Drotar DM, Williams MD, de Souza N, Brusko TM, Brusko MA, Wasserfall CH, Atkinson MA, Bodenmiller B. Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata. Nat Metab. 2026 Jul 2. doi: 10.1038/s42255-026-01559-z. Epub ahead of print. PMID: 42393283.

ORIGINAL

AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes

Ward C, Banks-Tibbs T, Thorpe H, Giles AM, Mabry SJ, Liu JJ, Chang HC, Yang J, Carney AF, Shaikh HM, Woolley LM, Joseph PN, Kozel J, Rocha EM, Rutter GA, Tseng GC, Liu S, Pless LL, Freyberg Z. AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes. bioRxiv [Preprint]. 2026 Jun 9:2026.06.05.730081. doi: 10.64898/2026.06.05.730081. PMID: 42327161; PMCID: PMC13277830.

ORIGINAL

A mitochondrial ROS-dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes

Wagner LE, Melnyk O, Muncy AN, Turner A, Duffett BE, Muralidharan C, Martinez-Irizarry MM, Arvin MC, Orr KS, Wu W, Manduchi E, Quesada-Masachs E, Piganelli JD, Kaestner KH, Brozinick JT, Linnemann AK. A mitochondrial ROS-dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes. Sci Transl Med. 2026 May 20;18(850):eadx7770. doi: 10.1126/scitranslmed.adx7770. Epub 2026 May 20. PMID: 42160450.

ORIGINAL

Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk

Syed F, Krishnan P, Chang G, Rana J, Langlais SR, Hati S, Yamada K, Lam AK, Talware S, Del Carmen Aquino J, Hagedorn E, Liu X, Sardar R, Liu J, Mirmira RG, Evans-Molina C. Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk. Diabetologia. 2026 Apr 21. doi: 10.1007/s00125-026-06720-7. Epub ahead of print. PMID: 42012684.

ORIGINAL

Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices

Becker MW, Brown ME, Wiseman K, Chiodetti AL, Huber MK, Cuaycal AE, Sintara P, Ferreira SM, Smurlick D, Barra JM, Ladd AM, Drotar DM, Atkinson MA, Weber P, Al-Mossawi H, Russ HA, Mahon TM, Brusko TM, Bossi G, Phelps EA. Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices. Sci Adv. 2026 Apr 3;12(14):eaec9029. doi: 10.1126/sciadv.aec9029. Epub 2026 Apr 1. PMID: 41920992; PMCID: PMC13041756.

ORIGINAL

Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development

Peters LD, Seay HR, Smith J, Posgai AL, Berkowitz R, Wasserfall CH, Atkinson MA, Bacher R, Brusko MA, Brusko TM. Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development. bioRxiv [Preprint]. 2026 Apr 1:2025.05.23.655848. doi: 10.1101/2025.05.23.655848. PMID: 41959012; PMCID: PMC13060253.

ORIGINAL

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Reardon S, Posgai AL, Bacher R, Luning Prak ET, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes. Cell Rep. 2026 Mar 23;45(4):117144. doi: 10.1016/j.celrep.2026.117144. Epub ahead of print. PMID: 41875135.

ORIGINAL

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Rawat P, Shapiro MR, Peters LD, Widrich M, Mayer-Blackwell K, Motwani K, Pavlović M, Al Hajj G, Posgai AL, Kanduri C, Isacchini G, Chernigovskaya M, Scheffer L, Motwani K, Balzano-Nogueira LO, Pettenger-Willey CM, Valkiers S, Jacobsen LM, Haller MJ, Schatz DA, Wasserfall CH, Emerson RO, Fiore-Gartland AJ, Atkinson MA, Klambauer G, Sandve GK, Greiff V, Brusko TM. Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood. Sci Adv. 2026 Feb 13;12(7):eadx7448. doi: 10.1126/sciadv.adx7448. Epub 2026 Feb 13. PMID: 41686902; PMCID: PMC12904210.

ORIGINAL

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis

Mummey HM, Corban S, Lucero J, Melton RL, Pittigher M, Johnston VC, Deutsch GH, D’Antonio-Chronowska A, Wang A, Hull-Meichle RL, Gaulton KJ. Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis. bioRxiv [Preprint]. 2025 Dec 16:2025.12.14.694120. doi: 10.64898/2025.12.14.694120. PMID: 41446239; PMCID: PMC12724667.