Our study aims are the following:
1. Histopathology review of pancreata from patients without diabetes (no diabetes and autoantibody+) and
those within the diabetic and other groups (type 1, type 2, gestational, other (those with unclassified diabetes,
excludes cystic fibrosis)).
2. Molecular profiling of PanNET for neuroendocrine hormones and other genes (Isl1, p53, Ki67), FISH
(telomerase shortening), MEN1 mutations (DNA), and gene expression (RNA). Assays will be conducted at the
University of Florida and Johns Hopkins laboratories.