Advances in 2D and 3D imaging techniques and technologies have enabled deeper interrogation of rare pancreas bioresources, highlighting significant gaps in our knowledge, with implications for the understanding of normal development and pancreatic disease. 3D volumetric imaging of the adult pancreas has revealed that 40–50% of the total endocrine objects within the organ consist of […]
Year: 2026
Role of pericytes in innate immune responses in pancreatic islets
Vascular defects are present in islets during stages 1 and 2 of type 1 diabetes, when symptomatic disease has not yet developed. However, the cellular and molecular mechanisms underlying vascular dysfunction and they link with autoimmunity have not been identified. This knowledge is crucial to understand T1D pathogenesis. In this proposal we plan to start […]
Enterovirus infection and pancreatic macrophage phenotypes in type 1 diabetes
Type 1 diabetes (T1D) is a chronic autoimmune disease targeting pancreatic beta cells. The incidence of T1D has been increasing, a trend inexplicable by genetic predisposition alone, indicating that environmental factors such as viruses play important roles in triggering the disease. Decades of research have provided epidemiological evidence for an association between T1D and enteroviruses, […]
Generation of a Comprehensive Atlas of the Human Pancreas in Type 2 Diabetes
Type 2 diabetes (T2D) is one of the most common chronic conditions worldwide, affecting hundreds of millions of people. It develops when the pancreas cannot produce enough insulin and/or when the body no longer responds to insulin effectively. While it is clear that insulin–producing β–cells fail in T2D, the reasons for this failure remain poorly […]
Role Integrated Stress Response Pathways in Health and Disease
Type 1 diabetes (T1D) development is characterized by insulitis, resulting in β–cell stress and progressive β–cell dysfunction and death. However, recent evidence suggest the role of pancreatic β cells in amplifying this immune response through the presentation of immunogenic peptides and secretion of cytokines and chemokines, indicating β cells may be complicit during the development […]