nPOD. Current nPOD Projects
- ImmTAAI technology and its potential use to treat autoimmunity
- Longitudinal Determination of Islet Specific protein expression in T1D
- Functional Role of CADM1 during Type 1 Diabetes Pathogenesis
- Innate immunity and diabetes
- Investigating the role of aggregation-prone proteins in pancreatic beta cell function and health
- Analysis of major digestive enzymes expression in human pancreas
- Beta Cell Senescence and T1D
- Microtubule-associated protein TAU and the Islets of Langerhans
- Decoding and Reprogramming Stem-Like Progenitor CD8 T cells Driving Type 1 Diabetes
- Probing the normal human pancreatic and islet matrisome throughout development
- Identification of novel monoclonal antibodies directed against pancreatic endocrine cell types for in vitroand in vivo analysis and targeting
- Transcription factor:coregulator interactions are compromised in islet cells under diabetogenic conditions
- Evaluation of Fatty Acid Levels in Human Pancreatic Tissue using Imaging Mass Spectrometry
- Insulin Receptor on T cells in T1D
- Credentialing immunotherapy targets in islet tissues with insulitis
- Validation of blood – derived single cell gene expression signature in peri – pancreatic lymph nodes of Type 1 Diabetes subjects
- Conversion of human acinar cells into insulin – producing cells
- Meta – proteomic biomarkers in stool for prediction of islet autoimmunity progression
- The role inflammatory signaling crosstalk on human exocrine and beta cells
- ORIGINAL: Proinsulin processing and presentation in human type 1 diabetes: a beta cell perspective ADDENDUM: Proinsulin processing and presentation in human type 1 diabetes: a beta cell perspective –T cell perspective
- Manipulating DNA damage-response signaling for the treatment of type 1 diabetes
- Changes in human islet microvasculature during the progression of type 1 diabetes
- Regulation of Islet Autophagy in Type 1 Diabetes
- Single cell analysis of the human pancreas in type 1 diabetes
- Assessing heterogeneity of DR3 haplotype risk in type 1 diabetes
- FOXO1 inhibition-mediated reprogramming of b-like cells in gastrointestinal tissues from type 1 diabetic donors
- Validating KIRAs as β-cell-sparing drugs in islets from human patients with T1D
- The cellular distribution of Golli protein in human pancreatic islets
- Modulation of autoimmune diabetes by natural antibodies specific for N-acetyl-D- glucosamine
- To identify T1D epitope using highly specific autoantibodies
- Dissecting the role intestinal NK cells play in T1D pathogenesis
- Transcriptional heterogeneity in the intact human pancreas
- High-resolution mapping of the human pancreatic magnetic resonance landscape
- Beta cell DNA double strand breaks in Type 1 diabetes
- Characterising the organisation of the gut associated lymphoid tissue in type 1 diabetes and tracking T and B cell receptor clonotype / isotype usage and islet antigen-specific lymphocytes across tissues in the nPOD resource.
- Role of Rab1A in Diabetes Mellitus
- Harnessing the power of beta cell regeneration to treat diabetes
- IGF receptor-like 1 and 2, new therapeutic targets for increasing insulin sensitivity and beta cell health
- Identification of HERV-W copies and insertion sites associated with T1D in human genomes
- CD3+CD56+ T lymphocytes, as novel T1D biomarker