Registration Closed The Network for Pancreatic Organ Donors with Diabetes (nPOD) is proud to host its 10th Annual Meeting at The Diplomat Beach Resort, February 20-23, 2018. Over the past eleven years, nPOD has made remarkable strides in terms of meeting its organizational goals. Key amongst these include seeing its investigators make discoveries that help […]
Year: 2017
nPOD Call for Co-Executive Director
JDRF-nPOD CALL FOR CO-EXCUTIVE DIRECTOR Preparing for the Next Era of nPOD Research To the Type 1 Diabetes Research and Care Community: We are pleased to announce the initiation of an open search for a new Co-Executive Director to join our leadership team at the Network for Pancreatic Organ donors with Diabetes (nPOD). Our hope […]
Role of CCL21 in Directing Immune Invasion of Pancreatic Islets
Type 1 diabetes results, at least in part, from invasion of pancreatic islets by T lymphocytes and antigen presenting cells (APCs) including macrophages and dendritic cells (DCs). What drives the migration of these immune cells into the islets remains unknown. A key step in the arrival of immune cells to a specific location is adhesion […]
Targeting Islet-Antigen Specific B Cells for Deletion as a Means to Prevent Type 1 Diabetes
Type 1 Diabetes (T1D) is an autoimmune disease in which the body attacks and destroys its own insulin-producing β-cells. It affects over 3 million people in the United States. For most T1D patients, it is extremely difficult to achieve normal glycemic control even with frequent blood glucose measurements, diet control, careful determination of insulin dosage, […]
2018 nPOD 10th Annual Scientific Meeting – Registration
Registration Information The Network for Pancreatic Organ Donors with Diabetes (nPOD) is proud to host its 10th Annual Meeting at The Diplomat Beach Resort, February 20-23, 2018. Over the past eleven years, nPOD has made remarkable strides in terms of meeting its organizational goals. Key amongst these include seeing its investigators make discoveries that help […]
Role of TMEM219 Expression in Type 1 Diabetes
The recent failure of immunotherapeutic strategies in the cure of T1D raised questions in considering autoimmunity the sole mechanism responsible for the pathogenesis of T1D. It has been recognized that activation of immune response against self-peptides is essential in the onset of T1D, but its role in the destruction of beta cells, which leads to […]
Expression of Beta-Cell Dedifferentiation-Associated microRNAs in Type 2 Diabetes
MicroRNAs are small endogenous RNAs which regulate gene expression through mRNA decay or translational inhibition. It has been previously demonstrated that microRNAs are pivotal regulators of cell phenotype and fate and are involved in many biological processes such as proliferation, differentiation or apoptosis in a wide type of cells and organisms. Given their prominent role […]
Characterization of T Cells that Recognize Post-Translationally Modified Beta Cell Epitopes from within the PLN
We have recently demonstrated that enzymatically modified peptides derived from beta cell antigens are preferentially recognized by autoreactive CD4+ T cell clones isolated from the peripheral blood of patients with T1D. Furthermore, T cells that recognize these modified peptides are present in the peripheral blood of patients with T1D and have a high affinity, enabling […]
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2017 Publications (36)
Jackson J, Posgai A, Campbell-Thompson M, Kusmartseva I. (2017) Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care. 2017 May;40(5):723-725. doi: 10.2337/dc16-2127. No Abstract Jackson J, Posgai A, Campbell-Thompson M, Kusmartseva I. (2017) Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. […]
nPOD Co-Executive Director Awarded the J. Enloe and Eugenia J. Dodson Chair in Diabetes Research
Congratulations to Alberto Pugliese, MD, of the University of Miami Miller School of Medicine’s Diabetes Research Institute, and Co-Executive Director of the Network for Pancreatic Organ Donors with Diabetes (nPOD), on this notable award! The endowed chair will help support Dr. Pugliese’s research in the area of immunology/immune tolerance issues related to Type 1 Diabetes. Click […]
Islet-Infiltrating T Cell Repertoire: Two Studies
DATE: Wednesday, January 11th, 2017 SPEAKERS: Sally Kent, PhD University of Massachusetts Medical School Maki Nakayama, MD, PhD University of Colorado Click here to view a recording of the webinar. Broad Repertoire of Autoreactive T Cells from the Islets of Donors with Type 1 Diabetes: In this webinar, we will be discussing our recent study on the […]