This study seeks to understand the immune cells important for beta cell loss by studying the function and type of cells present in lymphoid tissue.
Category: Immunology
Hybrid peptides as target antigens for pathogenic T cells in human T1D patients
We have recently discovered a new form of beta-cell autoantigen, which is recognized by CD4 T cells, and is formed through a novel post-translational modification of beta-cell peptides that involves the fusion between insulin peptide fragments and peptides of other secretory granule proteins. The hybrid insulin peptides (HIPs) are highly antigenic for autoreactive and pathogenic […]