Teresa Rodriguez-Calvo Instructor at the La Jolla Institute for Allergy & Immunology The JDRF-nPOD Scientists Who Seek the Cure for T1D Dr. Rodriguez-Calvo is a member of the La Jolla Institute’s Developmental Immunology – von Herrath Lab and a part of the nPOD-Viral working group. Read More
Year: 2015
nPOD Publications Reach 100
Dr. Martha Campbell-Thompson recently published the 100th nPOD publication: Organ donor specimens: What can they tell us about type 1 diabetes? Pediatric Diabetes 2015:16:320-330. “This mini-review will provide some key histopathological findings emanating from the nPOD collection, including the heterogeneity of beta cell loss and islet inflammation (or insulitis, shown in the image to the […]
nPOD Webinar- Immunosequencing: Generating a Potential New Class of Diagnostics
nPOD Webinar- Immunosequencing: Generating a Potential New Class of Diagnostics Date: Tuesday, December 15th, 2015 Time: 11:00AM (EST) – 12:00PM (EST) Speakers: Erik Yusko, PhD, Adaptative Biotechnologies and Todd Brusko, PhD, Universtity of Florida Find more information on the webinar and a link to the meeting here.
November 2015 Investigator Spotlight
David Leslie Professor of Diabetes and Autoimmunity and Diabetes Center Lead at the Blizard Institute The JDRF-nPOD Scientists Who Seek the Cure for T1D Dr. Leslie is an nPOD investigator at the Blizard Institute at the University of London. He is also a consultant physician at St. Bartholomew’s Hospital in London. Read More
Mononuclear phagocyte populations in T1D islets
Little is known about how T cell pathogenesis is modulated in the islets during T1D, yet this is a critical obstacle for preventing destruction of remaining islets or beta cell grafts. Therefore, we must elucidate mechanisms that promote and prevent the pathogenic autoimmune response in the islets. Our data in the NOD mouse model show […]
ORIGINAL: Growth and Development of the Endocrine Pancreas in Humans: Extrapolating Normal Physiology to the Regenerative Capacity of the Endocrine Compartment in Type 1 and Type 2 Diabetes; ADDENDUM: The Role of Neuropeptide Y (NPY) in Human Beta Cell Maturation and Diabetes Pathogenesis
ORIGINAL: Chromogranin A is a global marker of endocrine cells. Most endocrine cells in the pancreas, in addition to Chromogranin A, also express other hormones, Insulin and Glucagon being most frequent, with Pancreatic Polypeptide, Somatostatin and Ghrelin in smaller numbers of endocrine cells. We have found that in adult human pancreas a small number of […]
October 2015 Investigator Spotlight
Antonio Toniolo Researcher at the University of Insubria Medical School The JDRF-nPOD Scientists Who Seek the Cure for T1D Dr. Toniolo is an nPOD investigator at the University of Insubria Medical School in Varese, Italy. He studies viruses that may trigger diabetes and is a member of the nPOD-Virus group. Read More
Pancreatic antibacterial responses in T1D
The etiology of autoimmune diabetes is not known. However, the disease is accompanied by varying amounts of immune activation and inflammation. Although genetics clearly plays a role in determining who gets the disease, we do not know the instigating events. There has been a lot of investigation into the potential role of virus infections in […]
Diabetes Virus Detection Study (DiViD)
The Diabetes Virus Detection Study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes (T1D) for the presence of viruses. Surgical minimal pancreatic tail resection was performed in general anesthesia 3-9 weeks after onset of type 1 diabetes in six adult patients (age 24-35 years). Pancreatic tissues were […]
Immunoregulation of type 1 diabetes
Type 1 Diabetes (T1D) is a disease that results from the autoimmune destruction of insulin-producing beta cells in the pancreas. The current treatment for T1D does not cure the disease or prevent the possibility of other serious complications. The mechanism that leads to the loss of immune tolerance still remains unclear; scientists believe that both […]
September 2015 Investigator Spotlight
Abdu Hamad Associate Professor of Pathology and Medicine at Johns Hopkins University School of Medicine The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access to nPOD samples for their […]
NKG2D ligand expression in type 1 diabetes development
Recent evidence derived from animal models of type 1 diabetes indicates that interaction of immune cells expressing the protein known as NKG2D with cells expressing other proteins, termed NKG2D ligands, plays an essential role in initiating diabetes development. In an effort to define more precisely the role these proteins play in type 1 diabetes progression, […]
Role of environmental chemicals in the development of type 1 diabetes
There is a well-documented rise in the incidence of type 1 diabetes (T1D) in industrialized countries suggesting a role for environmental chemical exposures. Alarmingly, the increased incidence is seen mostly in children under age 5. However, research on environmental chemical exposures and T1D is very limited and there is an urgent need for research to […]
July 2015 Investigator Spotlight
Noel Morgan Director of the Institute of Biomedical and Clinical Science, University of Exeter Medical School The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access to nPOD samples for […]
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May 2015 Investigator Spotlight
Lydia Sorokin Director of Physiological Chemistry and Pathobiochemistry and Spokesperson of the Cells-in-Motion Cluster of Excellence at Universität, Münster, Germany The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access […]
April 2015 Investigator Spotlight
Heikki Hyöty M.D., PhD Professor at the University of Tampere, Finland The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access to nPOD samples for their work. We’ll let them […]
Detection of coxsackievirus infection in β-cells in T1D by short fluorescently labeled oligonucleotide probes
Type 1 diabetes (T1D) results from a complex interplay between genetic polymorphisms, immune system and environment. Viruses, mainly enteroviruses such as members of the Coxsackie B virus (CVB) family, have been suspected since long time to trigger diabetes and epidemiological studies support a causative role of viral infections during diabetes onset. Nonetheless, the presence of […]
Origin of composite islet structure in humans
In the adult human pancreas the majority of islets have a clear non-random organization of mantle of non beta cells around beta cell cores, with larger islets usually having multiple such subunits (composite) whereas smaller islets resembled the classic rodent pattern. There is far more variability in islet composition both within each human pancreas and […]
Beta-cell mass in Antibody-positive non-diabetic subjects
The question of the B-cell mass of non-diabetic autoantibody-positive (Ab+) subjects is crucial to understand both common forms of type 1 diabetes and latent autoimmune diabetes (LADA). It is well established that the presence of GAD Abs is not sufficient to predict diabetes or insulin dependency. Knowing the B cell mass of Ab+ donors could […]
Beta cell polarity
Insulin secretion is principally regulated by the beta cell response to glucose. This secretory response is multiphasic with an initial burst of insulin secretion followed by sustained or increasing secretion. This complex timing of secretion is important for body function and is lost in type 2 diabetes. Beta cells normally function, and are normally regulated, […]
nPOD Webinar: Using Pancreas Tissue Slices for in Situ Studies of Human Islet Cell Biology
nPOD Webinar: Using Pancreas Tissue Slices for in Situ Studies of Human Islet Cell Biology nPOD has scheduled a Webinar for Dr. Stephan Speier to discuss the Slice Technique he developed for pancreatic islets and exocrine. From Dr. Speier: “Pancreas tissue slices are 150-200µm thick sections of living pancreatic tissue obtained from animals or humans. […]
March 2015 Investigator Spotlight
Matthias von Herrath, MD Professor, La Jolla Institute; Vice President and Head, Seattle R&D Center NovoNordisk The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access to nPOD samples for […]
March 2015 Investigator Spotlight
Sally Kent, PhD Assistant Professor, University of Massachusetts Medical School The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access to nPOD samples for their work. We’ll let them introduce […]
2015 Publications (17)
Nagafuchi S, Toniolo A (2015). Viral diabetes: virus diabetogenicity and host susceptibility. Immunoendocrinology 2015; 2: e1026. doi: 10.14800/ie.1026. 1. Ramirez L, Hamad AR (2015). From non-obese diabetic to Network for the Pancreatic Organ Donors with Diabetes: New Heights in type 1 diabetes research. World Journal of Diabetes. 2015 Nov 25;6(16):1309-11. doi: 10.4239/wjd.v6.i16.1309. Kaddis JS, Pugliese A, […]
Epigenetic analysis of nPOD islet cells
Type 1 Diabetes (T1D) is a complex autoimmune disease affecting more than 30 million people worldwide. T1D is caused by a combination of genetic and epigenetic factors leading to immune destruction of insulin-secreting islet cells. Although significant progress has recently been made in elucidating the genetics of T1D, the non-genetics component has remained poorly defined. […]
Analysis of type 1 interferon responses to rotavirus in patients with type 1 diabetes
Rotavirus infection of children at-risk of type 1 diabetes is associated with disease progression. Similarly, infection of adult non-obese diabetic (NOD) mice with Rhesus monkey rotavirus RRV accelerates diabetes onset. This acceleration correlates with RRV spread to the mesenteric and pancreatic lymph nodes, where virus associates with and activates dendritic cells and induces B and […]
January 2015 Investigator Spotlight
Dr. Shannon Wallet, Ph.D. Associate Professor Department of Periodontology University of Florida The JDRF-nPOD Scientists Who Seek the Cure for T1D Each month, we highlight one of the nPOD investigators. Thanks to the fundraising of all the Breakthrough T1D chapters, these scientists are able to have access to nPOD samples for their work. We’ll let […]