Publications

Guyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA. T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes. Diabetologia. 2025 Jun 9. doi: 10.1007/s00125-025-06458-8. Epub ahead of print. PMID: 40490584.

Faraj N, Hoogaars WMH, Duinkerken BHP, Wolters AHG, Kats K, Dekkers MC, Zaldumbide A, Giepmans BNG. Pancreatic exocrine damage induces beta cell stress in zebrafish larvae. Diabetologia. 2025 Apr 28. doi: 10.1007/s00125-025-06432-4. Epub ahead of print. PMID: 40295334.

Jones TLZ, Kusmartseva I, Litovsky S, Thakar R, Posgai AL, Eckel RH, Atkinson MA. The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes. Diabetes. 2025 Apr 24:db250017. doi: 10.2337/db25-0017. Epub ahead of print. PMID: 40272262.

van der Heide V, McArdle S, Nelson MS, Cerosaletti K, Gnjatic S, Mikulski Z, Posgai AL, Kusmartseva I, Atkinson M, Homann D. Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression. bioRxiv [Preprint]. 2025 Mar 19:2025.03.18.644000. doi: 10.1101/2025.03.18.644000. PMID: 40166299; PMCID: PMC11956956.

Richardson SJ, Rodriguez-Calvo T, Laiho JE, Kaddis JS, Nyalwidhe JO, Kusmartseva I, Morfopoulou S, Petrosino JF, Plagnol V, Maedler K, Morris MA, Nadler JL, Atkinson MA, von Herrath M, Lloyd RE, Hyoty H, Morgan NG, Pugliese A; nPOD-Virus Group. Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06401-x. Epub ahead of print. PMID: 40090994.

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. bioRxiv [Preprint]. 2025 Mar 17:2025.02.13.637721. doi: 10.1101/2025.02.13.637721. PMID: 40027657; PMCID: PMC11870426.

Rodriguez-Calvo T, Laiho JE, Oikarinen M, Akhbari P, Flaxman C, Worthington T, Apaolaza P, Kaddis JS, Kusmartseva I, Tauriainen S, Campbell-Thompson M, Atkinson MA, von Herrath M, Hyöty H, Morgan NG, Pugliese A, Richardson SJ; nPOD-Virus group. Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06384-9. Epub ahead of print. PMID: 40090995.

Pala K, Sun KX, Krogvold L, Dahl-Jørgensen K, Reddy S. Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease. Cell Tissue Res. 2025 Mar 10. doi: 10.1007/s00441-025-03955-5. Epub ahead of print. PMID: 40059238.

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. bioRxiv [Preprint]. 2025 Mar 1:2024.12.29.630665. doi: 10.1101/2024.12.29.630665. PMID: 39763971; PMCID: PMC11703223.

Bahl V, Rifkind R, Waite E, Hamdan Z, May CL, Manduchi E, Voight BF, Lee MYY, Tigue M, Manuto N, Glaser B, Avrahami D, Kaestner KH. G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells. Sci Transl Med. 2025 Jan;17(779):eadi6148. doi: 10.1126/scitranslmed.adi6148. Epub 2025 Jan 1. PMID: 39742505.

Carré A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, Göransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells. Nat Commun. 2025 Jan 17;16(1):765. doi: 10.1038/s41467-025-55908-9. PMID: 39824805; PMCID: PMC11748642.

Akhtar MN, Hnatiuk A, Delgadillo-Silva L, Geravandi S, Sameith K, Reinhardt S, Bernhardt K, Singh SP, Maedler K, Brusch L, Ninov N. Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk. EMBO J. 2025 Feb;44(4):1131-1153. doi: 10.1038/s44318-024-00332-w. Epub 2025 Jan 6. PMID: 39762647; PMCID: PMC11833124.

Barlow GL, Schürch CM, Bhate SS, Phillips D, Young A, Dong S, Martinez HA, Kaber G, Nagy N, Ramachandran S, Meng J, Korpos E, Bluestone JA, Nolan GP, Bollyky PL. The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes. medRxiv [Preprint]. 2024 Dec 14:2023.03.15.23287145. doi: 10.1101/2023.03.15.23287145. Update in: Elife. 2025 Apr 15;13:RP100535. doi: 10.7554/eLife.100535. PMID: 36993739; PMCID: PMC10055577.

Duinkerken, B.H.P., Alsahaf, A.M.J., Hoogenboom, J.P. et al. Automated analysis of ultrastructure through large-scale hyperspectral electron microscopy. npj Imaging 2, 53 (2024). https://doi.org/10.1038/s44303-024-00059-7

Kang S, Penaloza Aponte JD, Elashkar O, Morales JF, Waddington N, Lamb DG, Ju H, Campbell-Thompson M, Kim S. Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes. J Pathol Inform. 2024 Nov 8;16:100406. doi: 10.1016/j.jpi.2024.100406. PMID: 39720415; PMCID: PMC11665367.

Apaolaza PS, Chen YC, Grewal K, Lurz Y, Boulassel S, Verchere CB, Rodriguez-Calvo T. Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes. Diabetologia. 2024 Oct 15. doi: 10.1007/s00125-024-06275-5. PMID: 39404844.

Crawford AJ, Forjaz A, Bons J, Bhorkar I, Roy T, Schell D, Queiroga V, Ren K, Kramer D, Huang W, Russo GC, Lee MH, Wu PH, Shih IM, Wang TL, Atkinson MA, Schilling B, Kiemen AL, Wirtz D. Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube. Sci Adv. 2024 Sep 27;10(39):eadp6285. doi: 10.1126/sciadv.adp6285. Epub 2024 Sep 27. PMID: 39331707; PMCID: PMC11430475.

Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN. m⁶A mRNA methylation by METTL14 regulates early pancreatic cell differentiation. EMBO J. 2024 Sep 25. doi: 10.1038/s44318-024-00213-2. Epub ahead of print. PMID: 39322760.

Raval K, Jamshidi N, Seyran B, Salwinski L, Pillai R, Yang L, Ma F, Pellegrini M, Shin J, Yang X, Tudzarova S. Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis. Life Sci Alliance. 2024 Sep 23;7(12):e202402743. doi: 10.26508/lsa.202402743. PMID: 39313296; PMCID: PMC11420665.

Golden GJ, Wu VH, Hamilton JT, Amses KR, Shapiro MR, Japp AS, Liu C, Pampena MB, Kuri-Cervantes L, Knox JJ, Gardner JS; HPAP Consortium; Atkinson MA, Brusko TM, Prak ETL, Kaestner KH, Naji A, Betts MR. Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset. bioRxiv [Preprint]. 2024 Sep 16:2024.04.23.590798. doi: 10.1101/2024.04.23.590798. Update in: Nat Commun. 2025 May 18;16(1):4621. doi: 10.1038/s41467-025-59626-0. PMID: 39345402; PMCID: PMC11429609.