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ORIGINAL

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

Quesada-Masachs E, Zilberman S, Chu T, McArdle S, Kiosses WB, Rajendran S, Atkinson MA, Benkahla MA, Mikulski Z, von Herrath M. Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes. bioRxiv [Preprint]. 2025 Sep 17:2025.09.13.676053. doi: 10.1101/2025.09.13.676053. PMID: 41000615; PMCID: PMC12458208.

ORIGINAL

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA. Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis. Cell Rep. 2025 Aug 26;44(9):116174. doi: 10.1016/j.celrep.2025.116174. Epub ahead of print. PMID: 40875294.

ORIGINAL

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes

Drotar DM, Vazquez Ramos GJA, Williams MD, David ST, Luce C, Smith JA, Posgai AL, Bacher R, Campbell-Thompson M, Kusmartseva I, Brusko MA, Atkinson MA, Wasserfall CH. Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes. Diabetes. 2025 Jul 24:db250326. doi: 10.2337/db25-0326. Epub ahead of print. PMID: 40705030.

ORIGINAL

The antigen presentation landscape of cytokine-stressed human pancreatic islets

Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ. The antigen presentation landscape of cytokine-stressed human pancreatic islets. Cell Rep. 2025 Jul 18;44(8):115927. doi: 10.1016/j.celrep.2025.115927. PMID: 40684438.

ORIGINAL

Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123

Álvarez-Cubela S, Altilio ID, Doke M, Klein D, Tamayo A, Alcázar Ó, Santana CG, Qadir MMF, Alver CG, Cruz F, Biggs O, Tovar Castro JD, Navarro-Rubio B, Ricordi C, Caicedo A, Buchwald P, Agarwal A, Oltra E, Pastori RL, Domínguez-Bendala J. Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123. Nat Commun. 2025 Jul 3;16(1):6121. doi: 10.1038/s41467-025-61534-2. PMID: 40610457; PMCID: PMC12226732.

ORIGINAL

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors

Swensen AC, Piehowski PD, Chen J, Chan XY, Kelly SS, Petyuk VA, Moore RJ, Nasif L, Butterworth EA, Atkinson MA, Kulkarni RN, Campbell-Thompson M, Mathews CE, Qian WJ. Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors. Diabetologia. 2025 Jul;68(7):1463-1475. doi: 10.1007/s00125-025-06417-3. Epub 2025 Jun 2. PMID: 40457096; PMCID: PMC12177028.

ORIGINAL

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

Golden GJ, Wu VH, Hamilton JT, Amses KR, Shapiro MR, Japp AS, Liu C, Pampena MB, Kuri-Cervantes L, Knox JJ, Gardner JS; HPAP Consortium; Atkinson MA, Brusko TM, Prak ETL, Kaestner KH, Naji A, Betts MR. Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset. bioRxiv [Preprint]. 2024 Sep 16:2024.04.23.590798. doi: 10.1101/2024.04.23.590798. Update in: Nat Commun. 2025 May 18;16(1):4621. doi: 10.1038/s41467-025-59626-0. PMID: 39345402; PMCID: PMC11429609.

ORIGINAL

The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes

Jones TLZ, Kusmartseva I, Litovsky S, Thakar R, Posgai AL, Eckel RH, Atkinson MA. The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes. Diabetes. 2025 Apr 24:db250017. doi: 10.2337/db25-0017. Epub ahead of print. PMID: 40272262.

ORIGINAL

The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

Barlow GL, Schürch CM, Bhate SS, Phillips D, Young A, Dong S, Martinez HA, Kaber G, Nagy N, Ramachandran S, Meng J, Korpos E, Bluestone JA, Nolan GP, Bollyky PL. The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes. medRxiv [Preprint]. 2024 Dec 14:2023.03.15.23287145. doi: 10.1101/2023.03.15.23287145. Update in: Elife. 2025 Apr 15;13:RP100535. doi: 10.7554/eLife.100535. PMID: 36993739; PMCID: PMC10055577.

ORIGINAL

Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue

Richardson SJ, Rodriguez-Calvo T, Laiho JE, Kaddis JS, Nyalwidhe JO, Kusmartseva I, Morfopoulou S, Petrosino JF, Plagnol V, Maedler K, Morris MA, Nadler JL, Atkinson MA, von Herrath M, Lloyd RE, Hyoty H, Morgan NG, Pugliese A; nPOD-Virus Group. Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06401-x. Epub ahead of print. PMID: 40090994.

ORIGINAL

Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes

Laiho JE, Oikarinen S, Morfopoulou S, Oikarinen M, Renner A, Depledge D, Ross MC, Gerling IC, Breuer J, Petrosino JF, Plagnol V, Pugliese A, Toniolo A, Lloyd RE, Hyöty H; JDRF nPOD-Virus Group. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv [Preprint]. 2024 Sep 13:2024.09.11.24313112. doi: 10.1101/2024.09.11.24313112. Update in: Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06359-w. PMID: 39314969; PMCID: PMC11419248.

ORIGINAL

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. bioRxiv [Preprint]. 2025 Mar 17:2025.02.13.637721. doi: 10.1101/2025.02.13.637721. PMID: 40027657; PMCID: PMC11870426.

ORIGINAL

Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes

Rodriguez-Calvo T, Laiho JE, Oikarinen M, Akhbari P, Flaxman C, Worthington T, Apaolaza P, Kaddis JS, Kusmartseva I, Tauriainen S, Campbell-Thompson M, Atkinson MA, von Herrath M, Hyöty H, Morgan NG, Pugliese A, Richardson SJ; nPOD-Virus group. Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes. Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06384-9. Epub ahead of print. PMID: 40090995.

ORIGINAL

Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata

Steenbuck N, Damond N, Engler S, Kusmartseva I, Posgai AL, Drotar DM, Williams MD, de Souza N, Brusko TM, Brusko MA, Wasserfall CH, Atkinson MA, Bodenmiller B. Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata. bioRxiv [Preprint]. 2025 Mar 05:2025.03.05.641526. doi: 10.1101/2025.03.05.641526.