Meeting Program
A special program open to all young investigators
Prior registration requested but not required
Carmella Evans-Molina MD, PhD
Co-Chairs: Sarah Richardson, PhD and Todd Brusko, PhD
Aqualea Grand Ballroom
Key Question 1 Introduction (1:45 PM – 1:55 PM)
Presenters: Sarah Richardson, PhD and Todd Brusko, PhD
Development of Adaptive Immunity During Childhood (1:55 PM – 2:20 PM)
Presenter: Joshua Gray, PhD
Age-Dependent Effects of Childhood Exposures on Islet Autoimmunity Risk (2:20 PM – 2:45 PM)
Presenter: Kendra Vehik, PhD
Islet Cellularity in Health and Disease (2:45 PM – 3:10 PM)
Presenter: Ulf Ahlgren, PhD
Co-Chairs: Sarah Richardson, PhD and Todd Brusko, PhD
Aqualea Grand Ballroom
Co-Chairs: Teresa Rodriguez-Calvo, PhD and Emily Sims, MD
Aqualea Grand Ballroom
Key Question 2 Introduction (4:15 PM – 4:25 PM)
Presenter: Teresa Rodriguez-Calvo, PhD and Emily Sims, MD
Courses and Consequences of Impaired Islet Prohormone Processing in T1D (4:25 PM – 4:50 PM)
Presenter: YC Chen, PhD
T Cell Recognition of Post-Translationally Modified and Misprocessed Prohormone Peptides (4:50 PM – 5:15 PM)
Presenter: Eddie James, PhD
Plasticity in Proglucagon Processing in Alpha-Cells (5:15 PM – 5:40 PM)
Presenter: Jonathan Campbell, PhD
Co-Chairs: Teresa Rodriguez-Calvo, PhD and Emily Sims, MD
Aqualea Grand Ballroom
Molecular Biology of Type 1 Diabetes Etiology
Presenter: Åke Lernmark, MD, PhD
Sky Terrace
Light hors d’oeuvres provided
Belleair Room
Led by: Amelia Linneman, PhD and Jessica Dunne, PhD
Madeira Room
Co-Chairs: Teresa Mastracci, PhD and Rebecca Hull, PhD
Aqualea Grand Ballroom
Key Question 3 Introduction (8:30 AM – 8:45 AM)
Presenter: Teresa Mastracci, PhD and Rebecca Hull, PhD
Pancreatitis and Diabetes: Overlap with Type 1 DM (8:45 AM – 9:10 AM)
Presenter: Melena Bellin, MD
Engineered Biomaterials to Explore the Islet-ECM Axis (9:10 AM – 9:35 AM)
Presenter: Nikki Farnsworth, PhD
Exocrine Studies in the Human Pancreas Slice (9:35 AM – 10:00 AM)
Presenter: Herbert Gaisano, PhD
Co-Chairs: Teresa Mastracci, PhD and Rebecca Hull, PhD
Aqualea Grand Ballroom
Co-Chairs: Maryaline Coffre, PhD and Dirk Homann, PhD
Efferocytosis Pathways in Islet Myeloid Cells Suppress Autoimmunity During Type 1 Diabetes (11:00 AM – 11:10 AM)
Presenter: Kristen Wells, PhD
Public B Cell Clones are Found in the Peripheral Blood and Pancreatic Lymph Nodes of T1D Donors (11:10 AM – 11:20 AM)
Presenter: Jessica Prendergast, PhD
TBA (11:20 AM – 11:30 AM)
Presenter: TBA
Competition Theme: “A Breakthrough for T1D Research”
Co-Chairs: Esther Latres, PhD and Mark Atkinson, PhD
Sharks: Ake Lernmark, MD, PhD, Lori Sussel, PhD, Timothy Tree, PhD, and Melena Bellin, PhD
Presenters: TBD
Aqualea Grand Ballroom
Belleair Room
Co-Chairs: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Aqualea Grand Ballroom
Key Question 4 Introduction (1:45 PM – 1:55 PM)
Presenter: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Molecular Architecture of Pancreatic Islet Cells Across Sex (1:55 PM – 2:20 PM)
Presenter: Fahd Qadir, PhD
Modeling Type 1 Diabetes in a Vascularized 3D Model of the Human Pancreatic Islet (2:20 PM – 2:45 PM)
Presenter: Chris Hughes, PhD
Mice with Human Immune System to Study the Thymic Development of Human Beta ACell Antigen-Reactive T Cells and Immune Infiltration of Stem Cell-Derived Beta Cells (2:45 PM – 3:10 PM)
Presenter: Remi Creusot, PhD
Modeling Lymph Node Function and Multi-Organ Immune Responses in Tissue Slices and Organs-On-Chip (3:10 PM – 3:35 PM)
Presenter: Rebecca Pompano, PhD
Co-Chairs: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Aqualea Grand Ballroom
Co-Chairs: Josh Vieth, PhD and Jamie Felton, MD
Aqualea Grand Ballroom
High-Throughput TCR Screening System for Linking Antigen Specificity and Phenotype of T Cells involved in the Pathogenesis of Type 1 Diabetes (4:30 PM – 4:40 PM)
Presenter: Maki Nakayama, MD
Spatial Interrogation of the Diabetic Hallmarks and Tissue Composition of Human Pancreas in 2D and 3D Using Deep Learning Models (4:40 PM – 4:50 PM)
Presenter: Yu Shen, PhD
Integrated Histopathology of the Human Pancreas Throughout Stages of Type 1 Diabetes Progression (4:50 PM – 5:00 PM)
Presenter: Verena van der Heide, PhD
STEM Cell-Derived Pancreatic β-Cells Overexpressing CD155 Demonstrate Enhanced Protection from Killing by Antigen-Specific T Cells (5:00 PM – 5:10 PM)
Presenter: Matthew Brown, BS
Mapping the Human Pancreas by Imaging Mass Cytometry Reveals Early Dysregulation in the Endocrine and Immune Compartment in Type 1 Diabetes Progression (5:10 PM – 5:20 PM)
Presenter: Nathan Steenbuck, PhD
TBA (5:20 PM – 5:30 PM)
Presenter: TBA
Includes annual meeting photo at sunset (Est. 6:30 PM)
Organized by: Alberto Pugliese, MD
Sky Terrace
Belleair Room
Co-Chairs: Roberto Mallone, MD, PhD, and Qizhi Tang, PhD
Aqualea Grand Ballroom
Key Question 5 Introduction (8:30 AM – 8:40 AM)
Presenter: Roberto Mallone, MD, PhD, and Qizhi Tang, PhD
Islet-Derived CD8+ T Cells from Donors with Type 1 Diabetes: Function and Reactivity (8:40 AM – 9:05 AM)
Presenter: Sally Kent, PhD
Targeted Modulation of Beta Cell Biology by Bifunctional RNA Therapeutics (9:05 AM – 9:30 AM)
Presenter: Paolo Serafini, PhD
Identification of T Cell Epitopes in T1D Using Synthetic Immunology (9:30 AM – 9:55 AM)
Presenter: Alok Joglekar, PhD
Beta-Cell Senescence in T1D: Friend or Foe? (9:55 AM – 10:20 AM)
Presenter: Feyza Engin, PhD
Co-Chairs: Roberto Mallone, MD, PhD, and Qizhi Tang, PhD
Aqualea Grand Ballroom
Co-Chairs: Sylvane You, PhD and Klaus Kaestner, PhD
Aqualea Grand Ballroom
Belleair Room
Led by: Al Powers, MD
Aqualea Grand Ballroom
Co-Chairs: Maria Redondo, MD, PhD, and Richard Oram, MD, PhD
Aqualea Grand Ballroom
Key Question 6 Introduction (2:30 PM – 2:40 PM)
Presenter: Maria Redondo, MD, PhD, and Richard Oram, MD, PhD
Sex Differences in Response to Beta-Cell Inflammation in T1D (2:40 PM – 3:05 PM)
Presenter: Raghu Mirmira, MD, PhD
T1D in Africa: Different in So Many Ways (3:05 PM – 3:30 PM)
Presenter: JC Katte, MD
What Does Diversity in nPOD Look Like? (3:30 PM – 3:55 PM)
Presenter: Irina Kusmartseva, PhD and John Kaddis, PhD
Co-Chairs: Maria Redondo, MD, PhD, and Richard Oram, MD, PhD
Aqualea Grand Ballroom
Heavy hors d’oeuvres provided
Siesta Key Room
Hotel checkout is 11 AM.
If checking out today, please bring luggage to the back of the meeting room for the remainder of the meeting.
Co-Chairs: TBA
TBA (9:00 AM – 9:10 AM)
Presenter: TBA
TBA (9:10 AM – 9:20 AM)
Presenter: TBA
TBA (9:20 AM – 9:30 AM)
Presenter: TBA
TBA (9:30 AM – 9:40 AM)
Presenter: TBA
Co-Chairs: TBA
Alberto Pugliese, MD, Mark Atkinson PhD, and Carmella Evans-Molina MD PhD
nPOD Executive Directors