Meeting Program
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Aqualea Prefunction West
Belleair Room
A special program open to all young investigators
Prior registration requested but not required
Madeira Room
Carmella Evans-Molina MD, PhD
Aqualea Grand Ballroom
Co-Chairs: Sarah Richardson, PhD and Todd Brusko, PhD
Aqualea Grand Ballroom
Key Question 1 Introduction (1:45 PM – 1:55 PM)
Presenters: Sarah Richardson, PhD and Todd Brusko, PhD
Development of Adaptive Immunity During Childhood (1:55 PM – 2:20 PM)
Presenter: Joshua Gray, PhD
Age-Dependent Effects of Childhood Exposures on Islet Autoimmunity Risk (2:20 PM – 2:45 PM)
Presenter: Kendra Vehik, PhD
Age-Related Immune and Tissue Signatures of Type 1 Diabetes (2:45 PM – 3:10 PM)
Presenter: Todd Brusko, PhD
Co-Chairs: Sarah Richardson, PhD and Todd Brusko, PhD
Aqualea Grand Ballroom
Co-Chairs: Emily Sims, MD and Clive Wasserfall, PhD
Aqualea Grand Ballroom
Key Question 2 Introduction (4:15 PM – 4:25 PM)
Presenter: Emily Sims, MD and Clive Wasserfall, PhD
Courses and Consequences of Impaired Islet Prohormone Processing in T1D (4:25 PM – 4:50 PM)
Presenter: YC Chen, PhD
T Cell Recognition of Post-Translationally Modified and Misprocessed Prohormone Peptides (4:50 PM – 5:15 PM)
Presenter: Eddie James, PhD
Plasticity in Proglucagon Processing in Alpha-Cells (5:15 PM – 5:40 PM)
Presenter: Jonathan Campbell, PhD
Co-Chairs: Emily Sims, MD and Clive Wasserfall, PhD
Aqualea Grand Ballroom
Jeffrey Krischer, MD, PhD
What questions should we be asking about T1D?
Lessons learned along the way
Aqualea Grand Ballroom
Sky Terrace
Light hors d’oeuvres provided
Aqualea Prefunction West
Belleair Room
Amelia Linnemann, PhD and Jessica Dunne, PhD
Madeira Room
Co-Chairs: Teresa Mastracci, PhD and Ben Giepmans, PhD
Aqualea Grand Ballroom
Key Question 3 Introduction (8:30 AM – 8:45 AM)
Presenter: Teresa Mastracci, PhD and Ben Giepmans, PhD
Pancreatitis and Diabetes: Overlap with Type 1 DM (8:45 AM – 9:10 AM)
Presenter: Melena Bellin, MD
Engineered Biomaterials to Explore the Islet-ECM Axis (9:10 AM – 9:35 AM)
Presenter: Nikki Farnsworth, PhD
Advancing the Use of Pancreas Slice Cultures to the Exocrine Pancreas (9:35 AM – 10:00 AM)
Presenter: Herbert Gaisano, MD
Co-Chairs: Teresa Mastracci, PhD and Ben Giepmans, PhD
Aqualea Grand Ballroom
Co-Chairs: Maryaline Coffre, PhD and Dirk Homann, PhD
Aqualea Grand Ballroom
Efferocytosis Pathways in Islet Myeloid Cells Suppress Autoimmunity During Type 1 Diabetes (11:00 AM – 11:10 AM)
Presenter: Kristen Wells, PhD
Public B Cell Clones are Found in the Peripheral Blood and Pancreatic Lymph Nodes of T1D Donors (11:10 AM – 11:20 AM)
Presenter: Jessica Prendergast, PhD
Pancreatic Stellate Cells May Contribute to Reduced Glucose-Stimulated Insulin Secretion in Type 1 Diabetes (11:20 AM – 11:30 AM)
Presenter: Alejandra Petrilli, PhD
Competition Theme: “A Breakthrough for T1D Research”
Co-Chairs: Esther Latres, PhD and Mark Atkinson, PhD
Sharks: Ake Lernmark, MD, PhD, Lori Sussel, PhD, Timothy Tree, PhD, and Melena Bellin, PhD
Presenters: Chaitra Rao, PhD, Alexandra Cuaycal, PhD, Debjyoti Kundu, PhD, and Melanie Shapiro, PhD
Aqualea Grand Ballroom
Belleair Room
Co-Chairs: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Aqualea Grand Ballroom
Key Question 4 Introduction (1:45 PM – 1:55 PM)
Presenter: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Molecular Architecture of Pancreatic Islet Cells Across Sex (1:55 PM – 2:20 PM)
Presenter: Fahd Qadir, PhD
Modeling Type 1 Diabetes in a Vascularized 3D Model of the Human Pancreatic Islet (2:20 PM – 2:45 PM)
Presenter: Chris Hughes, PhD
Mice with Human Immune System to Study the Thymic Development of Human Beta Cell Antigen-Reactive T Cells and Immune Infiltration of Stem Cell-Derived Beta Cells (2:45 PM – 3:10 PM)
Presenter: Remi Creusot, PhD
Modeling Lymph Node Function and Multi-Organ Immune Responses in Tissue Slices and Organs-On-Chip (3:10 PM – 3:35 PM)
Presenter: Rebecca Pompano, PhD
Co-Chairs: Juan Dominguez-Bendala, PhD and Alberto Pugliese, MD
Aqualea Grand Ballroom
Co-Chairs: Josh Vieth, PhD and Jamie Felton, MD
Aqualea Grand Ballroom
High-Throughput TCR Screening System for Linking Antigen Specificity and Phenotype of T Cells involved in the Pathogenesis of Type 1 Diabetes (4:30 PM – 4:40 PM)
Presenter: Maki Nakayama, MD
Spatial Interrogation of the Diabetic Hallmarks and Tissue Composition of Human Pancreas in 2D and 3D Using Deep Learning Models (4:40 PM – 4:50 PM)
Presenter: Yu Shen, BS
Integrated Histopathology of the Human Pancreas Throughout Stages of Type 1 Diabetes Progression (4:50 PM – 5:00 PM)
Presenter: Verena van der Heide, PhD
Stem Cell-Derived Pancreatic β-Cells Overexpressing CD155 Demonstrate Enhanced Protection from Killing by Antigen-Specific T Cells (5:00 PM – 5:10 PM)
Presenter: Matthew Brown, BS
Mapping the Human Pancreas by Imaging Mass Cytometry Reveals Early Dysregulation in the Endocrine and Immune Compartment in Type 1 Diabetes Progression (5:10 PM – 5:20 PM)
Presenter: Nathan Steenbuck, PhD
INS Genetic Variation Promotes Type 1 Diabetes Risk by Increasing Beta Cell Insulin Production, Hyperactivity, and Fragility (5:20 PM – 5:30 PM)
Presenter: James Johnson, PhD
Sky Terrace
Belleair Room
Co-Chairs: Qizhi Tang, PhD and Holger Russ, PhD
Aqualea Grand Ballroom
Key Question 5 Introduction (8:30 AM – 8:40 AM)
Presenter: Qizhi Tang, PhD and Holger Russ, PhD
Islet-Derived CD8+ T Cells from Donors with Type 1 Diabetes: Function and Reactivity (8:40 AM – 9:05 AM)
Presenter: Sally Kent, PhD
Defective Islet Autophagy as a Contributor to Beta Cell Immunogenicity (9:05 AM – 9:30 AM)
Presenter: Amelia Linnemann, PhD
Identification of T Cell Epitopes in T1D Using Synthetic Immunology (9:30 AM – 9:55 AM)
Presenter: Alok Joglekar, PhD
Beta-Cell Senescence in T1D: Friend or Foe? (9:55 AM – 10:20 AM)
Presenter: Feyza Engin, PhD
Co-Chairs: Qizhi Tang, PhD and Holger Russ, PhD
Aqualea Grand Ballroom
Co-Chairs: Sylvane You, PhD and Klaus Kaestner, PhD
Aqualea Grand Ballroom
Belleair Room
Molecular Biology of Type 1 Diabetes Etiology
Presenter: Åke Lernmark, MD, PhD
Aqualea Grand Ballroom
Co-Chairs: Maria Redondo, MD, PhD, and Richard Oram, MD, PhD
Aqualea Grand Ballroom
Key Question 6 Introduction (2:30 PM – 2:40 PM)
Presenter: Maria Redondo, MD, PhD, and Richard Oram, MD, PhD
Sex Differences in Response to Beta-Cell Inflammation in T1D (2:40 PM – 3:05 PM)
Presenter: Raghu Mirmira, MD, PhD
T1D in Africa: Different in So Many Ways (3:05 PM – 3:30 PM)
Presenter: JC Katte, MD
What Does Disease Heterogeneity in nPOD Look Like? (3:30 PM – 3:55 PM)
Presenter: Irina Kusmartseva, PhD and John Kaddis, PhD
Co-Chairs: Maria Redondo, MD, PhD, and Richard Oram, MD, PhD
Aqualea Grand Ballroom
Includes annual meeting photo at 4:30PM
Organized by: Alberto Pugliese, MD
Heavy hors d’oeuvres provided
Siesta Key Room
Madeira Room
Hotel checkout is 11 AM.
If checking out today, please bring luggage to the back of the meeting room for the remainder of the meeting.
Belleair Room
Klaus Kaestner, PhD
Aqualea Grand Ballroom
Co-Chairs: Bruce Verchere, PhD, and Anna Casu, MD
Aqualea Grand Ballroom
Are We Missing Something? Do the Small Things Matter? Loss of Extra-Islet Beta Cells in Type 1 Diabetes (9:00 AM – 9:10 AM)
Presenter: Teifion Luckett, PhD
Heterogeneity of β Cell Extracellular Vesicles in T1D: PD-L1 and HLA Class I Mediated Immunomodulation (9:10 AM – 9:20 AM)
Presenter: Chaitra Rao, PhD
β Cell Heterogeneity in the Acute IFN-α Response (9:200 AM – 9:30 AM)
Presenter: Leslie Wagner, PhD
Chromogranins and Secretogranins in the Pathogenesis of Type 1 Diabetes (9:30 AM – 9:40 AM)
Presenter: Patricia Velado, PhD
Functional Heterogeneity of Alpha Cells (9:40 AM – 9:50 AM)
Presenter: Julia Panzer, PhD
MALDI Imaging-Directed Spatial Biology: A New Lens to Redefine Alzheimer’s Disease Research and Therapeutic Directions
Led By: Ramon Sun, PhD
Aqualea Grand Ballroom
Co-Chairs: Mark Atkinson, PhD, Alberto Pugliese, MD, Carmella Evans-Molina, MD, PhD
Aqualea Grand Ballroom