JDRF - Juvenile Diabetes Research Foundation International - Dedicated to finding a cure.

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Immunology

Investigators in this group are using nPOD samples to try and understand what part the immune system plays in the development of type 1 diabetes.

Mercè Martì*
Manuela Battaglia* Michael Morran
Marwan Mounayar
Todd Brusko Maki Nakayama*
Damien Chaussabel Jerry Nepom
Jing Chen Massimo Pietropaolo
Raphael Clynes Alberto Pugliese
Howard Davidson* Helena Reijonen*
Thomas Donner Bart Roep*
Ivana Durinovic-Bello Carme Roura-Mir*
George Eisenbarth Suparna Sarkar*
Garry Fathman* Leonard Shultz
Dale Greiner Jo Spencer
Abdel Hamad Bradley Stone
Dirk Homann Mattias von Herrath
Dolores Jaraquemada* Thomas Waldmann
Sally Kent* Garth Warnock
Bill Kwok Clive Wasserfall
Joe Larkin, III Thomas Wight

 

 

 

Brigham and Women's Hospital

Project: Intrinsic immunoregulatory defect of bone marrow mesenchymal stem cells (BM-MSC) from T1D patients

Co-Investigator:
Marwan Mounayar, M.D.

 

 


 

 

University of California, San Francisco

Project: Identification of novel tissue-specific antigens expressed by human extrathymic Aire-expressing cells, and determination of their potential contribution to the prevention of type 1 diabetes

 

 


 

 

San Raffaele Scientific Institute

Project: Dissecting the effector/regulatory compartments in the target tissues of T1D

Co-Investigator:
Ezio Bonifacio, Ph.D.

 

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Ezio Bonifacio, Ph.D.
San Raffaele Scientific Institute

Project: Dissecting the effector/regulatory compartments in the target tissues of T1D

Prinicpal Investigator:
Manuela Battaglia, Ph.D.

 

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University of Florida

Project: Molecular signature of autoimmune T cells and type 1 diabetes

 

 

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Benaroya Research Institute

Project: Genetic modification and immunologic checkpoints of proinsulin response

Principal Investigator:
Ivana Durinovic-Bellò, Ph.D.

 

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Jing Chen, Ph.D.
NCI/NIH

Project: The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes

Pricipal Investigator:
Thomas Waldmann, M.D.

 

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Columbia University

Project: TCR signal transduction in diabetogenic T cells

 

 

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davidson

University of Colorado Health Science Center

Project: Characterization of autoantigen-specific T cell receptors from PLNs

 

 

 

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Johns Hopkins University

Project: Fas Ligand: Unorthodox target for prevention of type 1 diabetes

Principal Investigator:
Abdel Hamad, Ph.D.

 

 

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Ivana Durinovic-Bellò, Ph.D.
Benaroya Research Institute

Project: Genetic modification and immunologic checkpoints of proinsulin response

Co-Investigators:
Thomas Wight, Ph.D.
Damien Chaussabel, Ph.D.

 

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George Eisenbarth, M. D., Ph. D.
University of Colorado, Denver

Project: Prediction and prevention of type 1 (insulin-dependent) diabetes mellitus

 

 

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fathman

Stanford University

Project: Microarray analysis of PLN from autoantibody positive donors

 

 

 

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greiner

University of Massachusetts

Project: Diabetogenic function of autoimmue donor splenocytes in humanized mice

Co-Investigator:
Leonard Shultz, Ph.D.
Click here to read more about Dr. Greiner and his research.

 

 

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Abdel Hamad, Ph.D.
Johns Hopkins University

Project: Fas Ligand: Unorthodox target for prevention of type 1 diabetes

Co-Investigator:
Thomas Donner, M.D.

 

 

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Dirk Homann

University of Colorado Denver

Project: Pancreatic expression of chemokines in human type 1 diabetes

Principal Investigator:
Suparna Sarkar, MBBS, Ph.D.

 

 

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Dolores Jaraquemada, Ph.D.*
Universitat Autonoma de Barcelona

Project: Tracing effector and regulatory T cell populations in type 1 diabetes

Co-Investigators:
Mercè Martì, Ph.D.
Carme Roura-Mir, Ph.D.

 

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Sally Kent

University of Massachusetts Medical Center

Project: Investigation of ß cells in human islets and PLN in T1D

Click here to read more about Dr. Kent and her research.

 

 

 

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Benaroya Research Institute

Project: Systematic assessment of autoreactivity in human type 1 diabets

Principal Investigator:
Bradley Stone, Ph.D.

 

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University of Florida

Project: Direct replication of T cell receptors specific for type 1 diabetes

Principal Investigator:
Maki Nakayama, M.D., Ph.D.

 

 

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University of London

Project: Risk of autoimmune diseases and human self-antigen expression

 

 

 

 

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Mercè Martì, Ph.D. *
Universitat Autonoma de Barcelona

Project: Tracing effector and regulatory T cell populations in type 1 diabetes

Principal Investigator:
Dolores Jaraquemada, Ph.D.

 

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Michael Morran, Ph.D.
The Brehm Center for Diabetes Research, University of Michigan

Project: Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope

Principal Investigator:
Massimo Pietropaolo, M.D.

 

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Marwan Mounayar, M.D.
Brigham and Women's Hospital

Project: Intrinsic immunoregulatory defect of bone marrow mesenchymal stem cells (BM-MSC) from T1D patients

Principal Investigator:
Reza Abdi, M.D.

 

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Maki Nakayama

University of Colorado Health Science Center

Project: Direct replication of T cell receptors specific for type 1 diabetes

Co-Investigator:
Joe Larkin, III, Ph.D.

 

 

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nepom

Benaroya Research Institute at Virginia Mason

Project: TCR repertoire analysis in type 1 diabetes

 

 

 

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The Brehm Center for Diabetes Research, University of Michigan

Project: Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope

Co-Investigator:
Michael Morran, Ph.D.

 

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puglieses

Diabetes Research Institute, University of Miami

Project: Beta cells and autoimmunity correlations

 

 

 

 

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Helena Reijonen
Benaroya Research Institute at Virginia Mason

Project: Islet autoantigen specific T cells in progressors and non-progressors

Click here to read more about Dr. Reijonen and her research.

 

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Bart Roep, Ph.D., D.M.*
Leiden University

Project: Detection of islet autoreactive CD8 T-cells in insulitis versus periphery

 

 

 

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Carme Roura-Mir, Ph.D. *
Universitat Autonoma de Barcelona

Project: Tracing effector and regulatory T-cell populations in type 1 diabetes

Principal Investigator:
Dolores Jaraquemada, M.D., Ph.D.

 

 

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University of Colorado, Denver

Project: Pancreatic expression of chemokines in human type 1 diabetes

Co-Investigator:
Dirk Homann, M.D.

 

 

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Leonard Shultz, Ph.D.
University of Massachusetts

Project: Diabetogenic function of autoimmune donor splenocytes in humanized mice

Principal Investigator:
Dale Greiner, Ph.D.

 

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spencer

King's College London School of Medicine

Project: Phenotype, specificity,dDiversity and clonal spread of ß cells in type 1 diabetes

Click here to read more about Dr. Spencer and her research.

 

 

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Benaroya Research Institute

Project: Systematic assessment of autoreactivity in human type 1 diabets

Co-Investigators:
Bill Kwok, Ph.D.
Matthias von Herrath, M.D.

 

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vonherrath

La Jolla Institute for Allergy and Immunology, University of California, San Diego

Project 1: Tetramer Staining of Pre-diabetic Pancreata MHC

Project 2: Systematic assessment of autoreactivity in human type 1 diabetes
Project 2 Principal Investigator:
Bradley Stone, Ph.D.
Click here to read more about Dr. von Herrath and his research.

 

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NCI/NIH

Project: The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes

Co-Investigator:
Jing Chen, Ph.D.

 

 

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warnock

University of British Columbia

Project: Characterization of T-cell costimulatory molecules in pancreata from IAPCD

 

 

 

 

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University of Florida

Project: Humoral immunity in type 1 diabetes

 

 

 

 

 

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Thomas Wight, Ph.D.
Benaroya Research Institute

Project: Genetic modification and immunologic checkpoints of proinsulin response

Principal Investigator:
Ivana Durinovic-Bellò, Ph.D.

 

 

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*These investigators have received funding from the Juvenile Diabetes Research Foundation (JDRF).