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nPOD@pathology.ufl.edu
Immunology
Investigators in this group are using nPOD samples to try and understand what part the immune system plays in the development of type 1 diabetes.
| Brigham and Women's Hospital |
Project: Intrinsic immunoregulatory defect of bone marrow mesenchymal stem cells (BM-MSC) from T1D patients |
| Co-Investigator: Marwan Mounayar, M.D. |
| University of California, San Francisco |
Project: Identification of novel tissue-specific antigens expressed by human extrathymic Aire-expressing cells, and determination of their potential contribution to the prevention of type 1 diabetes |
| San Raffaele Scientific Institute |
Project: Dissecting the effector/regulatory compartments in the target tissues of T1D |
| Co-Investigator: Ezio Bonifacio, Ph.D. |
Ezio Bonifacio, Ph.D. |
|---|
| San Raffaele Scientific Institute |
Project: Dissecting the effector/regulatory compartments in the target tissues of T1D |
| Prinicpal Investigator: Manuela Battaglia, Ph.D. |
| University of Florida |
Project: Molecular signature of autoimmune T cells and type 1 diabetes |
| Benaroya Research Institute |
Project: Genetic modification and immunologic checkpoints of proinsulin response |
| Principal Investigator: Ivana Durinovic-Bellò, Ph.D. |
Jing Chen, Ph.D. |
|---|
| NCI/NIH |
Project: The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes |
| Pricipal Investigator: Thomas Waldmann, M.D. |
| Columbia University |
Project: TCR signal transduction in diabetogenic T cells |
| University of Colorado Health Science Center |
Project: Characterization of autoantigen-specific T cell receptors from PLNs |
| Johns Hopkins University |
Project: Fas Ligand: Unorthodox target for prevention of type 1 diabetes |
Principal Investigator: |
Ivana Durinovic-Bellò, Ph.D. |
|---|
| Benaroya Research Institute |
Project: Genetic modification and immunologic checkpoints of proinsulin response |
Co-Investigators: |
George Eisenbarth, M. D., Ph. D. |
|---|
| University of Colorado, Denver |
Project: Prediction and prevention of type 1 (insulin-dependent) diabetes mellitus |
| Stanford University |
Project: Microarray analysis of PLN from autoantibody positive donors |
| University of Massachusetts |
Project: Diabetogenic function of autoimmue donor splenocytes in humanized mice |
| Co-Investigator: Leonard Shultz, Ph.D. |
| Click here to read more about Dr. Greiner and his research. |
Abdel Hamad, Ph.D. |
|---|
| Johns Hopkins University |
Project: Fas Ligand: Unorthodox target for prevention of type 1 diabetes |
| Co-Investigator: Thomas Donner, M.D. |
| University of Colorado Denver |
Project: Pancreatic expression of chemokines in human type 1 diabetes |
| Principal Investigator: Suparna Sarkar, MBBS, Ph.D. |
Dolores Jaraquemada, Ph.D.* |
|---|
| Universitat Autonoma de Barcelona |
Project: Tracing effector and regulatory T cell populations in type 1 diabetes |
| Co-Investigators: Mercè Martì, Ph.D. Carme Roura-Mir, Ph.D. |
| University of Massachusetts Medical Center |
Project: Investigation of ß cells in human islets and PLN in T1D |
| Click here to read more about Dr. Kent and her research. |
| Benaroya Research Institute |
Project: Systematic assessment of autoreactivity in human type 1 diabets |
| Principal Investigator: Bradley Stone, Ph.D. |
| University of Florida |
Project: Direct replication of T cell receptors specific for type 1 diabetes |
| Principal Investigator: Maki Nakayama, M.D., Ph.D. |
| University of London |
Project: Risk of autoimmune diseases and human self-antigen expression |
Mercè Martì, Ph.D. * |
|---|
| Universitat Autonoma de Barcelona |
Project: Tracing effector and regulatory T cell populations in type 1 diabetes |
| Principal Investigator: Dolores Jaraquemada, Ph.D. |
Michael Morran, Ph.D. |
|---|
| The Brehm Center for Diabetes Research, University of Michigan |
Project: Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope |
| Principal Investigator: Massimo Pietropaolo, M.D. |
Marwan Mounayar, M.D. |
|---|
| Brigham and Women's Hospital |
Project: Intrinsic immunoregulatory defect of bone marrow mesenchymal stem cells (BM-MSC) from T1D patients |
| Principal Investigator: Reza Abdi, M.D. |
| University of Colorado Health Science Center |
Project: Direct replication of T cell receptors specific for type 1 diabetes |
| Co-Investigator: Joe Larkin, III, Ph.D. |
| Benaroya Research Institute at Virginia Mason |
Project: TCR repertoire analysis in type 1 diabetes |
| The Brehm Center for Diabetes Research, University of Michigan |
Project: Identification of T1D-specific Fab fragments of IA-2 dominant conformational epitope |
| Co-Investigator: Michael Morran, Ph.D. |
| Diabetes Research Institute, University of Miami |
Project: Beta cells and autoimmunity correlations |
| Benaroya Research Institute at Virginia Mason |
Project: Islet autoantigen specific T cells in progressors and non-progressors |
| Click here to read more about Dr. Reijonen and her research. |
Bart Roep, Ph.D., D.M.* |
|---|
| Leiden University |
Project: Detection of islet autoreactive CD8 T-cells in insulitis versus periphery |
Carme Roura-Mir, Ph.D. * |
|---|
| Universitat Autonoma de Barcelona |
Project: Tracing effector and regulatory T-cell populations in type 1 diabetes |
| Principal Investigator: Dolores Jaraquemada, M.D., Ph.D. |
| University of Colorado, Denver |
Project: Pancreatic expression of chemokines in human type 1 diabetes |
| Co-Investigator: Dirk Homann, M.D. |
Leonard Shultz, Ph.D. |
|---|
| University of Massachusetts |
Project: Diabetogenic function of autoimmune donor splenocytes in humanized mice |
| Principal Investigator: Dale Greiner, Ph.D. |
| King's College London School of Medicine |
Project: Phenotype, specificity,dDiversity and clonal spread of ß cells in type 1 diabetes |
| Click here to read more about Dr. Spencer and her research. |
| Benaroya Research Institute |
Project: Systematic assessment of autoreactivity in human type 1 diabets |
Co-Investigators: |
| La Jolla Institute for Allergy and Immunology, University of California, San Diego |
Project 1: Tetramer Staining of Pre-diabetic Pancreata MHC |
| Project 2: Systematic assessment of autoreactivity in human type 1 diabetes |
| Project 2 Principal Investigator: Bradley Stone, Ph.D. |
| Click here to read more about Dr. von Herrath and his research. |
| NCI/NIH |
Project: The role of IL-15 and IL-15Ra in the pathogenesis of type 1 diabetes |
| Co-Investigator: Jing Chen, Ph.D. |
| University of British Columbia |
Project: Characterization of T-cell costimulatory molecules in pancreata from IAPCD |
| University of Florida |
Project: Humoral immunity in type 1 diabetes |
Thomas Wight, Ph.D. |
|---|
| Benaroya Research Institute |
Project: Genetic modification and immunologic checkpoints of proinsulin response |
| Principal Investigator: Ivana Durinovic-Bellò, Ph.D. |
*These investigators have received funding from the Juvenile Diabetes Research Foundation (JDRF).
