nPOD https://validator.w3.org/feed/docs/rss2.html Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry Home Insulin is expressed by enteroendocrine cells during human fetal development Donor Groups Donor Groups DRAFT Who We Are Exploring miRNAs heterogeneity within pancreatic islet cells’ subpopulations in the context of T1D OCA-B/Pou2af1 Expression in T Cells Promotes PD-1 Blockade-Induced Autoimmunity but is Dispensable for Anti-Tumor Immunity Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection Publications LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development BET proteins are required for transcriptional activation of the senescent beta cell secretome in Type 1 Diabetes GLP-1R is downregulated in beta cells of NOD mice and T1D patients Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice Deep learning-powered quantification of endocrine cells and CD3+ T cells in the natural history of type 1 diabetes Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk Dysregulation of molecular and cellular pathways in the pancreas during type 1 diabetes ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas Contact Us Eisenbarth nPOD Award Recipients Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression Organ Donor Registration New Faces at nPOD Cores Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices Improving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes Autoimmune interactions between the HLA-DQβ157 polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes Redox Regulation of m6A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes How We Work Proteomic and mass spectrometry-based identification of viral proteins in human tissue samples from the Network for Pancreatic Organ Donors with Diabetes De-differentiation of cryopreserved splenocytes to iPSC as an isogenic resource for differentiation to sc-islets. Addendum: De-differentiation of cryopreserved islet-derived T cell lines to iPSC as a resource for differentiation to sc-islets 3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1 Small things matter: Lack of extra-islet beta cells in Type 1 diabetes Age-related heterogeneity of type 1 diabetes: a multi-omics, spatially resolved, exploration of the human pancreas at disease onset Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifs FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues Precision-engineered biomimetics: the human fallopian tube m6A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes ENTPD3-specific CAR regulatory T cells for local immune control in T1D Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods Transcriptional control of T cell tissue adaptation and effector function in infants and adults Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes